2-BroMo-1,3-dichloro-5-Methoxybenzene

Base Information

• Chemical Name: 2-BroMo-1,3-dichloro-5-Methoxybenzene
• CAS No.: 174913-20-3
• Molecular Formula: C7H5BrCl2O
• Molecular Weight: 255.924
• Hs Code.: 2909309090
• Mol file: 174913-20-3.mol

Synonyms:2-BroMo-1,3-dichloro-5-Methoxybenzene

Chemical Property of 2-BroMo-1,3-dichloro-5-Methoxybenzene

Chemical Property:

• Melting Point: 59-60 °C(Solv: methanol (67-56-1))
• Boiling Point: 293.2±35.0 °C(Predicted)
• PSA: 9.23000
• Density: 1.666±0.06 g/cm3(Predicted)
• LogP: 3.76450
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-1,3-dichloro-5-methoxybenzene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BroMo-1,3-dichloro-5-Methoxybenzene

There total 2 articles about 2-BroMo-1,3-dichloro-5-Methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

3,5-dichloroanisole (33719-74-3) → 4-bromo-3,5-dichloroanisole (174913-20-3) + C7H5BrCl2O (73931-43-8)

Guidance literature:

With hydrogenchloride; N-Bromosuccinimide; In water; acetone; at 20 ℃; for 0.5h;

DOI:10.1055/s-0030-1258454

Reference yield:

3,5-dichloroanisole (33719-74-3) → 4-bromo-3,5-dichloroanisole (174913-20-3)

Guidance literature:

With hydrogenchloride; N-Bromosuccinimide; In water; acetone; at 20 ℃; for 0.5h;

Reference yield:

4-bromo-3,5-dichloroanisole (174913-20-3) + aniline (62-53-3) → N-Phenyl-(2,6-dichloro-4-methoxy)-aniline (136099-56-4)

Guidance literature:

4-bromo-3,5-dichloroanisole; aniline; With sodium t-butanolate; In toluene; for 0.5h; Inert atmosphere;

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In toluene; for 18h; Reflux;

upstream raw materials:

3,5-dichloroanisole

Downstream raw materials:

N-Phenyl-(2,6-dichloro-4-methoxy)-aniline

Refernces

• 1、 Tietze, Lutz F.,Vock, Carsten A.,Krimmelbein, Ilga K.,Nacke, Linda. "Synthesis of novel structurally simplified estrogen analogues with electron-donating groups in ring A". experimental part. p. 2040 - 2060. Retrieved 2009/12/27.