(2S)-1,2,3,4-TETRAHYDRO-6-METHOXY-2-NAPHTHALENAMINE HYDROCHLORIDE

Base Information

• Chemical Name: (2S)-1,2,3,4-TETRAHYDRO-6-METHOXY-2-NAPHTHALENAMINE HYDROCHLORIDE
• CAS No.: 168252-26-4
• Molecular Formula: C₁₂H₁₅NO₃
• Molecular Weight: 221.256
• Mol file: 168252-26-4.mol

Synonyms:(2S)-1,2,3,4-TETRAHYDRO-6-METHOXY-2-NAPHTHALENAMINE HYDROCHLORIDE;(S)-(-)-6-METHOXY-2-AMINOTETRALIN HYDROCHLORIDE;(S)-6-METHOXY-1,2,3,4-TETRAHYDRO-NAPHTHALEN-2-YLAMINE HYDROCHLORIDE;(S)-6-METHOXY-2-AMINOTETRALIN HYDROCHLORIDE

Chemical Property of (2S)-1,2,3,4-TETRAHYDRO-6-METHOXY-2-NAPHTHALENAMINE HYDROCHLORIDE

Chemical Property:

• PSA: 72.55000
• LogP: 1.66630

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-1,2,3,4-TETRAHYDRO-6-METHOXY-2-NAPHTHALENAMINE HYDROCHLORIDE

There total 3 articles about (2S)-1,2,3,4-TETRAHYDRO-6-METHOXY-2-NAPHTHALENAMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3',4'-dihydro-6'-methoxyspiro-2,5-dione (144646-02-6) → 2-amino-1,2,3,4-tetrahydro-6-methoxynaphthalene-2-carboxylic acid (35581-10-3,168252-26-4)

Guidance literature:

With barium dihydroxide; In water; at 125 ℃; for 24h;

DOI:10.1002/hlca.19920750522

Reference yield:

6-methoxy-2-tetralone (2472-22-2) → 2-amino-1,2,3,4-tetrahydro-6-methoxynaphthalene-2-carboxylic acid (35581-10-3,168252-26-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / (NH₄)2CO₃ / ethanol; H₂O / 18 h / 80 °C

2: 85 percent / Ba(OH)2 / H₂O / 24 h / 125 °C

With barium dihydroxide; ammonium carbonate; In ethanol; water;

DOI:10.1002/hlca.19920750522

Reference yield:

→ 2-amino-1,2,3,4-tetrahydro-6-methoxynaphthalene-2-carboxylic acid (35581-10-3,168252-26-4)

Guidance literature:

Hydantoin 26, NaOH, Propylenglykol;

upstream raw materials:

3',4'-dihydro-6'-methoxyspiro-2,5-dione

6-methoxy-2-tetralone

Downstream raw materials:

methyl 2-amino-6-methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate hydrochloride

Refernces

• 1、 Obrecht,Spiegler,Schonholzer,Muller,Heimgartner,Stierli. "A new general approach to enantiomerically pure cyclic and open-chain (R)- and (S)-α,α-disubstituted α-amino acids". . p. 1666 - 1696. Retrieved 2007/10/02.