SAR407899

Base Information

• Chemical Name: SAR407899
• CAS No.: 923359-38-0
• Molecular Formula: C14H16N2O2
• Molecular Weight: 244.29
• Mol file: 923359-38-0.mol

Synonyms:6-(piperidin-4-yloxy)isoquinolin-1(2H)-one

Chemical Property of SAR407899

Chemical Property:

• Boiling Point: 517.8±50.0 °C(Predicted)
• PKA: 12.79±0.20(Predicted)
• PSA: 54.12000
• Density: 1.193±0.06 g/cm3(Predicted)
• LogP: 1.98770

Purity/Quality:

97% ^*data from raw suppliers

SAR407899 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of SAR407899

There total 8 articles about SAR407899 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C19H24N2O4 → SAR-407899 (923359-38-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2010.12.104

Reference yield:

6-methoxy-2H-isoquinolin-1-one (26829-43-6) → SAR-407899 (923359-38-0)

Guidance literature:

Multi-step reaction with 3 steps

1: boron tribromide

2: PS-BEMP / acetonitrile / 160 °C

3: trifluoroacetic acid / dichloromethane

With boron tribromide; trifluoroacetic acid; In dichloromethane; acetonitrile;

DOI:10.1016/j.bmcl.2010.12.104

Reference yield:

3-methoxycinnamic acid (6099-04-3,17570-26-2) → SAR-407899 (923359-38-0)

Guidance literature:

Multi-step reaction with 5 steps

1: diphenylphosphoranyl azide; triethylamine / toluene

2: Diphenylmethane / 250 °C

3: boron tribromide

4: PS-BEMP / acetonitrile / 160 °C

5: trifluoroacetic acid / dichloromethane

With Diphenylmethane; diphenylphosphoranyl azide; boron tribromide; triethylamine; trifluoroacetic acid; In dichloromethane; toluene; acetonitrile;

DOI:10.1016/j.bmcl.2010.12.104

upstream raw materials:

6-methoxy-2H-isoquinolin-1-one

3-methoxycinnamic acid

3-methoxy-cinnamic acid methyl ester

1-((E)-2-Isocyanato-vinyl)-3-methoxy-benzene