1,6-Dihydro-4-hydroxy-2-methyl-6-oxo-1-phenyl-3-pyridinecarboxylic acid ethyl ester

Base Information

Chemical Name:1,6-Dihydro-4-hydroxy-2-methyl-6-oxo-1-phenyl-3-pyridinecarboxylic acid ethyl ester
CAS No.:1153-83-9
Molecular Formula:C15H15NO4
Molecular Weight:273.28
Hs Code.:
Mol file:1153-83-9.mol

Synonyms:1,6-Dihydro-4-hydroxy-2-methyl-6-oxo-1-phenyl-3-pyridinecarboxylic acid ethyl ester;3-Pyridinecarboxylic acid,1,6-dihydro-4-hydroxy-2-methyl-6-oxo-1-phenyl-,ethyl ester

Suppliers and Price of 1,6-Dihydro-4-hydroxy-2-methyl-6-oxo-1-phenyl-3-pyridinecarboxylic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 7 raw suppliers

Chemical Property of 1,6-Dihydro-4-hydroxy-2-methyl-6-oxo-1-phenyl-3-pyridinecarboxylic acid ethyl ester

Chemical Property:

Melting Point:175 °C
Boiling Point:388.4±42.0 °C(Predicted)
PKA:4.50±1.00(Predicted)
PSA：68.53000
Density:1.302±0.06 g/cm3(Predicted)
LogP:2.02820

Purity/Quality:: 98%,99%, ^*data from raw suppliers

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Technology Process of 1,6-Dihydro-4-hydroxy-2-methyl-6-oxo-1-phenyl-3-pyridinecarboxylic acid ethyl ester

There total 1 articles about 1,6-Dihydro-4-hydroxy-2-methyl-6-oxo-1-phenyl-3-pyridinecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1153-83-9
4-hydroxy-2-methyl-6-oxo-1-phenyl-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester

Guidance literature:: 3-Anilino-crotonsaeureethylester, Kohlensuboxid, abs. Ae.;
DOI:10.1007/BF00904722

Reference yield: 86.0%

: 106-47-8
4-chloro-aniline

: 1153-83-9
4-hydroxy-2-methyl-6-oxo-1-phenyl-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester

: 122-51-0
orthoformic acid triethyl ester

: 73754-46-8
3-(p-Chloranilinomethylen)-6-methyl-1-phenyl-2,4-dioxo-2H,4H-pyridin-5-carbonsaeureethylester

Guidance literature:: In acetic acid; at 90 - 100 ℃; for 0.5h;
DOI:10.1007/BF00938720

Reference yield:

: 1153-83-9
4-hydroxy-2-methyl-6-oxo-1-phenyl-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester

: 73754-65-1
8-Ethoxycarbonyl-7-methyl-1-phenyl-2,5-dioxo-2H,5H-pyrano<3,2-c>pyridin-3-carbonitril

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / acetic acid / 0.5 h / 90 - 100 °C

2: 1.) KOC(CH₃)3 / 1.) DMF; 2.) DMF, 60 min, 80 - 90 deg C

With potassium tert-butylate; In acetic acid;
DOI:10.1007/BF00938720