DIHYDRO-ARTEMISININ GLUCURONIDE

Base Information

• Chemical Name: DIHYDRO-ARTEMISININ GLUCURONIDE
• CAS No.: 198976-06-6
• Molecular Formula: C₂₁H₃₂O₁₁
• Molecular Weight: 460.478
• Mol file: 198976-06-6.mol

Synonyms:DIHYDRO-ARTEMISININ GLUCURONIDE;(3R,5aS,6R,8aS,9S,12R,12aS)-Decahydro-3,6,9-trimethyl- 3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl b-D-Glucopyranosiduronic Acid;Dihydro Artemisinin b-D-Glucuronide (Mixture of Isomers);(3R,5aS,6R,8aS,9S,12R,12aS)-Decahydro-3,6,9-trimethyl- 3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl -D-Glucopyranosiduronic Acid;Dihydro Artemisinin -D-Glucuronide (Mixture of Isomers)

Chemical Property of DIHYDRO-ARTEMISININ GLUCURONIDE

Chemical Property:

• PSA: 153.37000
• LogP: 0.10320
• Storage Temp.: -20°C Freezer
• Solubility.: Methanol, Water

Purity/Quality:

98%Min ^*data from raw suppliers

Dihydroartemisinin glucuronide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A metabolite of Dihydro Artemisinin. Antimalarial. A metabolite of Dihydro Artemisinin. Antimalarial

Technology Process of DIHYDRO-ARTEMISININ GLUCURONIDE

There total 10 articles about DIHYDRO-ARTEMISININ GLUCURONIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

methyl 1-(dihydroartemisinin-12β-yl)-2,3,4-tri-O-acetyl-β-D-glucopyranuronate (163659-94-7) → β-dihydroartemisinin β-glucuronide (198976-06-6)

Guidance literature:

With sodium carbonate; In methanol; at 0 - 20 ℃; for 4h;

DOI:10.1021/jm001061a

Reference yield:

methyl 1-(dihydroartemisinin-12α-yl)-2,3,4-tri-O-acetyl-β-D-glucopyranuronate (163562-58-1) → 1-(dihydroartemisinin-12α-yl)-β-D-glucopyranuronic acid (198976-06-6)

Guidance literature:

With sodium carbonate; In methanol; at 0 - 20 ℃; for 4h;

DOI:10.1021/jm001061a

Reference yield:

dihydroartemisinin (71939-50-9) → 1-(dihydroartemisinin-12α-yl)-β-D-glucopyranuronic acid (198976-06-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 78 percent / ZnCl₂ / 1,2-dichloro-ethane / 4 h / -15 - 10 °C

2: 11 percent / ZnCl₂ / 1,2-dichloro-ethane / 4 h / 0 - 10 °C

3: aq. Na₂CO₃ / methanol / 4 h / 0 - 20 °C

With sodium carbonate; zinc(II) chloride; In methanol; 1,2-dichloro-ethane;

DOI:10.1021/jm001061a

upstream raw materials:

methyl 1-(dihydroartemisinin-12α-yl)-2,3,4-tri-O-acetyl-β-D-glucopyranuronate

dihydroartemisinin

C₂₈H₄₀O₁₄

methyl 1-(dihydroartemisinin-12β-yl)-2,3,4-tri-O-acetyl-β-D-glucopyranuronate

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