NA

Base Information

• Chemical Name: NA
• CAS No.: 30198-93-7
• Molecular Formula: C11H18N4
• Molecular Weight: 206.291
• Mol file: 30198-93-7.mol

Synonyms:2-(4-pyridin-4-yl-piperazin-1yl)-ethylamine;2-(4-pyridin-4-ylpiperazin-1-yl)ethylamine;2-(4-pyridin-4-yl-piperazin-1-yl)-ethylamine;

Chemical Property of NA

Chemical Property:

• PSA: 45.39000
• LogP: 0.86550

Purity/Quality:

4-(4-pyridinyl)-1-Piperazineethanamine 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of NA

There total 4 articles about NA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-(4-(pyridin-4-yl)piperazin-1-yl)acetonitrile (1067659-05-5) → 2-(4-(pyridin-4-yl)piperazin-1-yl)ethanamine (30198-93-7)

Guidance literature:

With hydrogen; In methanol; for 12h; under 3102.97 Torr; Autoclave;

DOI:10.1016/j.bmc.2010.06.025

Reference yield: 63.0%

2-(2-(4-(pyridin-4-yl)piperazin-1-yl)ethyl)isoindoline-1,3-dione (942613-36-7) → 2-(4-(pyridin-4-yl)piperazin-1-yl)ethanamine (30198-93-7)

Guidance literature:

With hydrazine; In ethanol; for 2h; Reflux;

DOI:10.1002/anie.201701905

Reference yield:

4-(piperazin-1-yl)pyridine (1008-91-9) → 2-(4-(pyridin-4-yl)piperazin-1-yl)ethanamine (30198-93-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 24 h / 70 °C

2: hydrazine / ethanol / 2 h / Reflux

With potassium carbonate; potassium iodide; hydrazine; In ethanol; N,N-dimethyl-formamide;

DOI:10.1002/anie.201701905

upstream raw materials:

2-(2-(4-(pyridin-4-yl)piperazin-1-yl)ethyl)isoindoline-1,3-dione

2-(4-(pyridin-4-yl)piperazin-1-yl)acetonitrile

4-(piperazin-1-yl)pyridine

Downstream raw materials:

C₂₈H₃₁Cl₂N₅O₃S