3-Oxazolidinecarboxylic acid, 5-forMyl-2,2-diMethyl-, phenylMethyl ester, (5S)-

Base Information

Chemical Name:3-Oxazolidinecarboxylic acid, 5-forMyl-2,2-diMethyl-, phenylMethyl ester, (5S)-
CAS No.:134038-74-7
Molecular Formula:C14H17NO4
Molecular Weight:263.293
Hs Code.:
Mol file:134038-74-7.mol

Synonyms:3-Oxazolidinecarboxylic acid, 5-forMyl-2,2-diMethyl-, phenylMethyl ester, (5S)-;benzyl (5S)-5-formyl-2,2-dimethyl-1,3-oxazolidine-3-carboxylate;(S)-Benzyl 5-formyl-2,2-dimethyloxazolidine-3-carboxylate

Suppliers and Price of 3-Oxazolidinecarboxylic acid, 5-forMyl-2,2-diMethyl-, phenylMethyl ester, (5S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

Total 8 raw suppliers

Chemical Property of 3-Oxazolidinecarboxylic acid, 5-forMyl-2,2-diMethyl-, phenylMethyl ester, (5S)-

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of 3-Oxazolidinecarboxylic acid, 5-forMyl-2,2-diMethyl-, phenylMethyl ester, (5S)-

There total 10 articles about 3-Oxazolidinecarboxylic acid, 5-forMyl-2,2-diMethyl-, phenylMethyl ester, (5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 134038-73-6
benzyl (S)-5-hydroxymethyl-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

: 134038-74-7
benzyl (S)-5-formyl-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 25 ℃; for 18h; Inert atmosphere;
DOI:10.1002/ejoc.201201413

Reference yield: 88.0%

: 135582-88-6
(S)-3-benzyloxycarbonyl-5-methoxycarbonyl-2,2-dimethyl-1,3-oxazolidine

: 134038-74-7
benzyl (S)-5-formyl-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -78 ℃; for 3h;
DOI:10.1021/jo900263s

Reference yield:

: 134038-71-4
(S)-4-benzyloxycarbonylaminomethyl-2,2-dimethyl-1,3-dioxolane

: 134038-74-7
benzyl (S)-5-formyl-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / 1 N HCl / dioxane; H₂O / 2 h / Heating

2: 75 percent / pyridine / CH₂Cl₂ / 2 h / Ambient temperature

3: 79 percent / Et₂O*BF₃ / acetone / 24 h / Ambient temperature

4: 92 percent / 1 N aq. LiOH / tetrahydrofuran / 1 h / Ambient temperature

5: 62 percent / DCC, DMSO, dichloroacetic acid / benzene / 2 h / 0 - 20 °C

With pyridine; hydrogenchloride; dichloro-acetic acid; lithium hydroxide; boron trifluoride diethyl etherate; dimethyl sulfoxide; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetone; benzene;
DOI:10.1055/s-1991-26480