6-butyl-4-hydroxy-3-methoxycarbonyl-7-beta-phenoxyethoxyquinoline

Base Information

Chemical Name:6-butyl-4-hydroxy-3-methoxycarbonyl-7-beta-phenoxyethoxyquinoline
CAS No.:19828-70-7
Molecular Formula:C₂₃H₂₅NO₅
Molecular Weight:395.455
Hs Code.:2933499090
Mol file:19828-70-7.mol

Synonyms:WR 197236

Suppliers and Price of 6-butyl-4-hydroxy-3-methoxycarbonyl-7-beta-phenoxyethoxyquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-butyl-4-hydroxy-3-methoxycarbonyl-7-beta-phenoxyethoxyquinoline

Chemical Property:

Vapor Pressure:1.39E-12mmHg at 25°C
Boiling Point:560.3°C at 760 mmHg
Flash Point:292.7°C
PSA：77.62000
Density:1.189g/cm³
LogP:4.11510

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 6-butyl-4-hydroxy-3-methoxycarbonyl-7-beta-phenoxyethoxyquinoline

There total 10 articles about 6-butyl-4-hydroxy-3-methoxycarbonyl-7-beta-phenoxyethoxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 19828-70-7,28130-28-1
methyl-6-butyl-4-oxo-7-(2-phenoxyethoxy)-1,4-dihydroquinoline-3-carboxylate

Guidance literature:: In toluene; at 270 ℃; for 0.0833333h; Microwave irradiation;

Reference yield:

: 1349820-40-1
N-(4-butyl-3-(2-phenoxyethoxy)phenyl)acetamide

: 19828-70-7,28130-28-1
methyl-6-butyl-4-oxo-7-(2-phenoxyethoxy)-1,4-dihydroquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / ethanol; water / 0 °C / Reflux

2.1: ethanol / Reflux

2.2: 0.2 h / Reflux

With potassium hydroxide; In ethanol; water; 2.1: Gould-Jacobs reaction;
DOI:10.1021/jm200718m

Reference yield:

: 28583-62-2
N-(4-butyryl-3-hydroxyphenyl)acetamide

: 19828-70-7,28130-28-1
methyl-6-butyl-4-oxo-7-(2-phenoxyethoxy)-1,4-dihydroquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / 0.5 h / 0 °C

2.1: palladium 10% on activated carbon; hydrogen / acetic acid / 3102.97 Torr

3.1: sodium hydride / N,N-dimethyl-formamide / 0 - 75 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: potassium hydroxide / ethanol; water / 0 °C / Reflux

5.1: ethanol / Reflux

5.2: 0.2 h / Reflux

With sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; sodium hydride; potassium hydroxide; In ethanol; water; acetic acid; N,N-dimethyl-formamide; 5.1: Gould-Jacobs reaction;
DOI:10.1021/jm200718m