t-Butyl 1,3-dihydroisoindole-2-carboxylate

Base Information

• Chemical Name: t-Butyl 1,3-dihydroisoindole-2-carboxylate
• CAS No.: 260412-75-7
• Molecular Formula: C13H17NO2
• Molecular Weight: 219.283
• Hs Code.: 2933990090
• Mol file: 260412-75-7.mol

Synonyms:t-Butyl 1,3-dihydroisoindole-2-carboxylate;1,3-Dihydro-isoindole-2-carboxylic acid tert-butyl ester;tert-Butyl isoindoline-2-carboxylate;2H-Isoindole-2-carboxylic acid, 1,3-dihydro-, 1,1-dimethylethyl ester

Chemical Property of t-Butyl 1,3-dihydroisoindole-2-carboxylate

Chemical Property:

• PSA: 29.54000
• LogP: 2.87520

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl1,3-Dihydroisoindole-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of t-Butyl 1,3-dihydroisoindole-2-carboxylate

There total 2 articles about t-Butyl 1,3-dihydroisoindole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

isoindoline (496-12-8) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl isoindoline-2-carboxylate (260412-75-7)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1021/jacs.8b04890

Reference yield: 27.0%

di-tert-butyl dicarbonate (24424-99-5) + 2-methylbenzylazide (126799-83-5) → tert-butyl isoindoline-2-carboxylate (260412-75-7) + N-(tert-butoxycarbonyl)-2-methylbenzylamine (138350-83-1)

Guidance literature:

With [5,10,15,20-tetrakis(2',4',6-trimethylphenyl)porphinato]cobalt(II); In toluene; at 100 ℃; for 16h; Catalytic behavior; Schlenk technique; Inert atmosphere;

DOI:10.1002/chem.201700358

Reference yield: 90.0%

tert-butyl isoindoline-2-carboxylate (260412-75-7) + (4-methoxy)benzenesulfonylmethanal O-benzyl oxime → C21H24N2O3

Guidance literature:

With 4-Benzoylpyridine; In tetrahydrofuran; at 20 ℃; for 6h; Inert atmosphere; UV-irradiation;

DOI:10.1002/anie.201603810

upstream raw materials:

isoindoline

di-tert-butyl dicarbonate

2-methylbenzylazide

Downstream raw materials:

diphenyl(pyridin-4-yl)methanol

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