TRANS (1S,2S)-1N-CBZ-CYCLOHEXANE-1,2-DIAMINE

Base Information

Chemical Name:TRANS (1S,2S)-1N-CBZ-CYCLOHEXANE-1,2-DIAMINE
CAS No.:199336-05-5
Molecular Formula:C14H20N2O2
Molecular Weight:248.32
Hs Code.:
Mol file:199336-05-5.mol

Synonyms:TRANS (1S,2S)-1N-CBZ-CYCLOHEXANE-1,2-DIAMINE;N-[(1S,2S)-2-aminocyclohexyl]-Carbamic Acid Phenylmethyl Ester

Suppliers and Price of TRANS (1S,2S)-1N-CBZ-CYCLOHEXANE-1,2-DIAMINE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-[(1S,2S)-2-aminocyclohexyl]-CarbamicAcidPhenylmethylEster
25g
$ 1470.00

American Custom Chemicals Corporation
TRANS (1S,2S)-1N-CBZCYCLOHEXANE-1,2-DIAMINE 95.00%
5MG
$ 504.00

Total 4 raw suppliers

Chemical Property of TRANS (1S,2S)-1N-CBZ-CYCLOHEXANE-1,2-DIAMINE

Chemical Property:

Boiling Point:409.5±44.0 °C(Predicted)
PKA:12.05±0.40(Predicted)
PSA：64.35000
Density:1.13±0.1 g/cm3(Predicted)
LogP:3.27390

Purity/Quality:

99% ^*data from raw suppliers

N-[(1S,2S)-2-aminocyclohexyl]-CarbamicAcidPhenylmethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses N-[(1S,2S)-2-aminocyclohexyl]-Carbamic Acid Phenylmethyl Ester is a reagent in the synthesis of the anti-cancer agent AA005 derivatives. also used in the preparation of pirenzepine analogs, as antimuscarinics.

Technology Process of TRANS (1S,2S)-1N-CBZ-CYCLOHEXANE-1,2-DIAMINE

There total 4 articles about TRANS (1S,2S)-1N-CBZ-CYCLOHEXANE-1,2-DIAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: benzyl tert-butyl ((1S,2S)-cyclohexane-1,2-diyl)dicarbamate

: 199336-05-5,1353973-30-4,445479-92-5
benzyl N-[(1S,2S)-2-aminocyclohexyl]carbamate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 2h;
DOI:10.1002/ejoc.201403415

Reference yield: 43.0%

: 21436-03-3
(S,S)-1,2-diaminocyclohexane

: 501-53-1,94274-21-2
benzyl chloroformate

: 199336-05-5,1353973-30-4,445479-92-5
benzyl N-[(1S,2S)-2-aminocyclohexyl]carbamate

Guidance literature:: With methanesulfonic acid; potassium acetate; bromocresol green; In 1,2-dimethoxyethane; ethanol; water; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2008.06.025

Reference yield:

: 180683-64-1
tert-butyl ((1S,2S)-2-aminocyclohexyl)carbamate

: 199336-05-5,1353973-30-4,445479-92-5
benzyl N-[(1S,2S)-2-aminocyclohexyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / water; 1,4-dioxane / 18.5 h / 0 - 25 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 25 °C

With sodium carbonate; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water;
DOI:10.1002/ejoc.201403415