2-Chloro-5-[[5-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-4-oxo-2-thiazolyl]amino]benzoicacid

Base Information

• Chemical Name: 2-Chloro-5-[[5-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-4-oxo-2-thiazolyl]amino]benzoicacid
• CAS No.: 331002-70-1
• Molecular Formula: C₂₃H₁₆ClN₃O₆S
• Molecular Weight: 497.916
• Mol file: 331002-70-1.mol

Synonyms:2-Chloro-5-[[5-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-4-oxo-2-thiazolyl]amino]benzoicacid

Chemical Property of 2-Chloro-5-[[5-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-4-oxo-2-thiazolyl]amino]benzoicacid

Chemical Property:

• PSA: 166.51000
• LogP: 6.51390
• Storage Temp.: Store at -20°C
• Solubility.: Soluble in DMSO

Purity/Quality:

97% ^*data from raw suppliers

PT1 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-5-[[5-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-4-oxo-2-thiazolyl]amino]benzoicacid

There total 5 articles about 2-Chloro-5-[[5-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-4-oxo-2-thiazolyl]amino]benzoicacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

5-(4,5-dimethyl-2-nitro-phenyl)-furan-2-carbaldehyde (1242840-80-7) + 2-chloro-5-(4-oxo-thiazolidin-2-ylideneamino)-benzoic acid (1266374-59-7) → 2-chloro-5-{5-[5-(4,5-dimethyl-2-nitro-phenyl)-furan-2-ylmethylene]-4-oxo-thiazolidin-2-ylideneamino}-benzoic acid (331002-70-1)

Guidance literature:

With sodium acetate; In acetic acid; for 2h; Inert atmosphere; Reflux;

DOI:10.1021/ml400028q

Reference yield:

2-furanoic acid (88-14-2) → 2-chloro-5-{5-[5-(4,5-dimethyl-2-nitro-phenyl)-furan-2-ylmethylene]-4-oxo-thiazolidin-2-ylideneamino}-benzoic acid (331002-70-1)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride; sodium nitrite / water / 0.17 h / Cooling with ice

2: dimethyl sulfide borane / tetrahydrofuran / 2.5 h / 50 - 60 °C / Inert atmosphere

3: sodium acetate / acetic acid / 2 h / Inert atmosphere; Reflux

With hydrogenchloride; sodium acetate; dimethyl sulfide borane; sodium nitrite; In tetrahydrofuran; water; acetic acid;

DOI:10.1021/ml400028q

Reference yield:

2-chloro-5-aminobenzoic acid (89-54-3) → 2-chloro-5-{5-[5-(4,5-dimethyl-2-nitro-phenyl)-furan-2-ylmethylene]-4-oxo-thiazolidin-2-ylideneamino}-benzoic acid (331002-70-1)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / Reflux; Inert atmosphere

2: sodium acetate / acetic acid / 2 h / Inert atmosphere; Reflux

With sodium acetate; In ethanol; acetic acid;

DOI:10.1021/ml400028q

upstream raw materials:

2-chloro-5-aminobenzoic acid

5-(4,5-dimethyl-2-nitro-phenyl)-furan-2-carbaldehyde

2-chloro-5-(4-oxo-thiazolidin-2-ylideneamino)-benzoic acid

4,5-dimethyl-2-nitrobenzenamine

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