5-AMINOMETHYL-THIOPHENE-3-CARBONITRILE

Base Information

• Chemical Name: 5-AMINOMETHYL-THIOPHENE-3-CARBONITRILE
• CAS No.: 232280-88-5
• Molecular Formula: C6H6N2S
• Molecular Weight: 138.19
• Hs Code.: 2934999090
• Mol file: 232280-88-5.mol

Synonyms:5-aminomethyl-3-cyanothiophene;2-aminomethyl-4-chlorophenylamine;2-amino-5-chlorobenzylamine;2-aminomethyl-4-cyanothiophene;

Chemical Property of 5-AMINOMETHYL-THIOPHENE-3-CARBONITRILE

Chemical Property:

• PSA: 78.05000
• LogP: 1.77878

Purity/Quality:

97% ^*data from raw suppliers

5-Aminomethyl-thiophene-3-carbonitrile 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-AMINOMETHYL-THIOPHENE-3-CARBONITRILE

There total 7 articles about 5-AMINOMETHYL-THIOPHENE-3-CARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.8%

C6H4N4S → 5-(aminomethyl)-3-thiophenecarbonitrile (232280-88-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 0 - 20 ℃; for 1h;

Reference yield: 50.0%

2-aminomethyl-4-cyanothiophene hydrochloride (203792-27-2) → 5-(aminomethyl)-3-thiophenecarbonitrile (232280-88-5)

Guidance literature:

With hydrogenchloride; In metha0; at 0 - 4 ℃;

Reference yield:

4-Bromothiophen-2-aldehyde (18791-75-8) → 5-(aminomethyl)-3-thiophenecarbonitrile (232280-88-5)

Guidance literature:

Multi-step reaction with 5 steps

1: NaBH₄ / methanol / 20 °C

2: dimethylformamide / Heating

3: CBr₄; PPh₃ / CH₂Cl₂

4: NaH / tetrahydrofuran

5: TFA / CH₂Cl₂

With sodium tetrahydroborate; carbon tetrabromide; sodium hydride; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 4: Gabriel-type amination;

DOI:10.1016/S0960-894X(02)00093-8

upstream raw materials:

4-Bromothiophen-2-aldehyde

(4-bromothiophen-2-yl)methanol

5-(hydroxymethyl)thiophene-3-carbonitrile

5-(bromomethyl)thiophene-3-carbonitrile

Downstream raw materials:

C₂₇H₃₆N₈O₂S₂

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