Isonicotinohydroxamic acid

Base Information

• Chemical Name: Isonicotinohydroxamic acid
• CAS No.: 4427-22-9
• Molecular Formula: C6H6N2O2
• Molecular Weight: 138.126
• Hs Code.: 2933399090
• NSC Number: 91840
• UNII: F0UQ8FE3Y1
• DSSTox Substance ID: DTXSID20196095
• Nikkaji Number: J68.810J
• Wikidata: Q27215667
• ChEMBL ID: CHEMBL454652
• Mol file: 4427-22-9.mol

Synonyms:Isonicotinohydroxamic acid;4427-22-9;Isonicotinylhydroxamic acid;N-Hydroxy-4-pyridinecarboxamide;N-hydroxypyridine-4-carboxamide;4-Pyridinecarboxamide, N-hydroxy-;Pyridine-4-carbohydroxamic acid;M 838;NSC 91840;4-Pyridinecarboxamide,N-hydroxy-(9CI);F0UQ8FE3Y1;4-Pyridinecarbohydroxamic acid;NSC-91840;N-Hydroxyisonicotinamide;4-pyridinecarbohydroxamic;N-hydroxy isonicotinamide;4-Pyridinehydroxamic acid;N-Hydroxyisonicotinamide #;UNII-F0UQ8FE3Y1;NCIOpen2_001496;Oprea1_256417;CHEMBL454652;SCHEMBL2998145;4-PICOLINEHYDROXAMIC ACID;DTXSID20196095;CHEBI:125317;NSC91840;Pyridine-4-carboxamide, N-hydroxy-;PYRIDINIUM-4-HYDROXAMIC ACID;AKOS000184484;LS-85031;CS-0290172;FT-0744917;EN300-1294295;BRD-K55478147-001-01-9;Q27215667

Chemical Property of Isonicotinohydroxamic acid

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 62.22000
• Density: 1.328g/cm³
• LogP: 0.59150
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 138.042927438
• Heavy Atom Count: 10
• Complexity: 121

Purity/Quality:

99% ^*data from raw suppliers

N-HYDROXY-4-PYRIDINECARBOXAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=CC=C1C(=O)NO

Technology Process of Isonicotinohydroxamic acid

There total 6 articles about Isonicotinohydroxamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-pyridinecarboxylic acid, methyl ester (2459-09-8) → 4-pyridinecarbohydroxamic acid (4427-22-9)

Guidance literature:

With hydroxylamine; In methanol; at 20 ℃; for 72h;

DOI:10.1007/s00775-020-01805-z

Reference yield: 91.0%

pyridine-4-carbaldehyde (872-85-5) → 4-pyridinecarbohydroxamic acid (4427-22-9)

Guidance literature:

With menadione; hydroxylamine hydrochloride; water; silver nitrate; triethylamine; In tetrahydrofuran; ethanol; at 20 ℃; for 0.5h; Irradiation; Green chemistry;

DOI:10.1007/s11164-018-3549-z

Reference yield: 86.0%

pyridine-4-carboxylic acid (55-22-1) → 4-pyridinecarbohydroxamic acid (4427-22-9)

Guidance literature:

pyridine-4-carboxylic acid; With 4-(Methylamino)pyridine; diisopropyl-carbodiimide; In dichloromethane; at 20 ℃;

With hydroxylamine; In dichloromethane; water; at 20 ℃; Further stages.;

DOI:10.1016/j.tetlet.2007.12.073

upstream raw materials:

4-pyridinecarboxylic acid, methyl ester

isonicotinic acid ethylester

pyridine-4-carboxylic acid

pyridine-4-carbaldehyde

Downstream raw materials:

4-hydroxamido-N-methylpyridinium iodide

4-Hydroxycarbamoyl-1-methyl-pyridinium; chloride

4-aminopyridine

1,3-bis(pyridin-4-yl)urea