2-(chloromethyl)-5-methylpyrazine hydrochloride

Base Information

• Chemical Name: 2-(chloromethyl)-5-methylpyrazine hydrochloride
• CAS No.: 128229-06-1
• Molecular Formula: C6H8Cl2N2
• Molecular Weight: 179.049
• Hs Code.: 2933990090
• Mol file: 128229-06-1.mol

Synonyms:2-(chloromethyl)-5-methylpyrazine hydrochloride

Chemical Property of 2-(chloromethyl)-5-methylpyrazine hydrochloride

Chemical Property:

• PSA: 25.78000
• LogP: 2.32580
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-(chloromethyl)-5-methylpyrazinehydrochloride,95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(chloromethyl)-5-methylpyrazine hydrochloride

There total 1 articles about 2-(chloromethyl)-5-methylpyrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-dimethyl-pyrazine (123-32-0) → 2-(chloromethyl)-5-methylpyrazine hydrochloride (128229-06-1)

Guidance literature:

With hydrogenchloride; sulfuryl dichloride; dilauryl peroxide; Yield given. Multistep reaction; 1) CCl₄, reflux, 1 h;

DOI:10.1055/s-1990-26830

Reference yield: 82.0%

2-(chloromethyl)-5-methylpyrazine hydrochloride (128229-06-1) → 2-methylpyrazin-5-carboxylic acid (5521-55-1)

Guidance literature:

With potassium carbonate; In water; tert-butyl alcohol; at 60 ℃; Ni-anode, 12 mA/cm²;

DOI:10.1055/s-1990-26830

Reference yield:

[5-(piperidin-4-yl)-1H-benzimidazol-2-yl]{4-[4-(trifluoromethyl)benzyl]piperazin-1-yl}methanone + 2-(chloromethyl)-5-methylpyrazine hydrochloride (128229-06-1) → (6-{1-[(5-methylpyrazin-2-yl)methyl]piperidin-4-yl}-1H-benzimidazol-2-yl){4-[4-(trifluoromethyl)benzyl]piperazin-1-yl}methanone trihydrochloride

Guidance literature:

[5-(piperidin-4-yl)-1H-benzimidazol-2-yl]{4-[4-(trifluoromethyl)benzyl]piperazin-1-yl}methanone; 2-(chloromethyl)-5-methylpyrazine hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃; for 120h;

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 0.166667h;

upstream raw materials:

2,5-dimethyl-pyrazine

Downstream raw materials:

2-methylpyrazin-5-carboxylic acid

Refernces