2,2-Dimethyl-5-(pyridin-3-ylaminomethylene)-[1,3]dioxane-4,6-dione

Base Information

• Chemical Name: 2,2-Dimethyl-5-(pyridin-3-ylaminomethylene)-[1,3]dioxane-4,6-dione
• CAS No.: 25063-68-7
• Molecular Formula: C₁₂H₁₂N₂O₄
• Molecular Weight: 248.238
• Mol file: 25063-68-7.mol

Synonyms:2,2-Dimethyl-5-(pyridin-3-ylaminomethylene)-[1,3]dioxane-4,6-dione

Chemical Property of 2,2-Dimethyl-5-(pyridin-3-ylaminomethylene)-[1,3]dioxane-4,6-dione

Chemical Property:

• PSA: 77.52000
• LogP: 1.28650
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

2,2-Dimethyl-5-((pyridin-3-ylamino)methylene)-1,3-dioxane-4,6-dione 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2-Dimethyl-5-(pyridin-3-ylaminomethylene)-[1,3]dioxane-4,6-dione

There total 2 articles about 2,2-Dimethyl-5-(pyridin-3-ylaminomethylene)-[1,3]dioxane-4,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

pyridin-3-ylamine (462-08-8) + cycl-isopropylidene malonate (2033-24-1) + orthoformic acid triethyl ester (122-51-0) → 2,2-dimethyl-5-[(pyridin-3-ylamino)methylidene]-1,3-dioxane-4,6-dione (25063-68-7)

Guidance literature:

cycl-isopropylidene malonate; orthoformic acid triethyl ester; at 90 ℃; for 1.5h; Large scale;

pyridin-3-ylamine; In ethanol; at 60 - 70 ℃; for 0.666667h; Large scale;

Reference yield:

→ 2,2-dimethyl-5-[(pyridin-3-ylamino)methylidene]-1,3-dioxane-4,6-dione (25063-68-7)

Guidance literature:

Isopropylidenmalonat, entspr. Aminopyridin, (EtO)3CH;

Reference yield: 75.0%

2,2-dimethyl-5-[(pyridin-3-ylamino)methylidene]-1,3-dioxane-4,6-dione (25063-68-7) → 4-oxo-1,4-dihydro-1,5-naphthyridine (16795-72-5)

Guidance literature:

With dowtherm A; at 250 ℃; for 1h; Inert atmosphere;

upstream raw materials:

pyridin-3-ylamine

cycl-isopropylidene malonate

orthoformic acid triethyl ester

Downstream raw materials:

1,7-naphthyridin-4-ol

4-hydroxy-1,5-naphthyridine

4-chloro-1,5-naphthyridine

4-mercapto-1,5-naphthyridine