3'-BROMO-3-PHENYLPROPIOPHENONE

Base Information

• Chemical Name: 3'-BROMO-3-PHENYLPROPIOPHENONE
• CAS No.: 866821-66-1
• Molecular Formula: C15H13BrO
• Molecular Weight: 289.172
• Mol file: 866821-66-1.mol

Synonyms:3'-BROMO-3-PHENYLPROPIOPHENONE

Chemical Property of 3'-BROMO-3-PHENYLPROPIOPHENONE

Chemical Property:

• Vapor Pressure: 9.9E-07mmHg at 25°C
• Boiling Point: 403.8°C at 760 mmHg
• Flash Point: 76.6°C
• Density: 1.349g/cm³

Purity/Quality:

95% ^*data from raw suppliers

3'-Bromo-3-phenylpropiophenone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3'-BROMO-3-PHENYLPROPIOPHENONE

There total 11 articles about 3'-BROMO-3-PHENYLPROPIOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-(3-bromophenyl)-3-phenylprop-2-en-1-one (22966-26-3,72758-66-8,25023-37-4) → 1-(3-bromophenyl)-3-phenylpropan-1-one (866821-66-1)

Guidance literature:

With formic acid; potassium ethyl xanthogenate; In N,N-dimethyl-formamide; at 130 ℃; for 1h; chemoselective reaction;

DOI:10.1021/acs.orglett.9b00635

Reference yield: 85.0%

1-(3-Bromophenyl)ethanone (2142-63-4) + benzyl alcohol (100-51-6,185532-71-2) → 1-(3-bromophenyl)-3-phenylpropan-1-one (866821-66-1)

Guidance literature:

With bis(μ-chloro)-bis[1,3-di(2-pyridyl)-4,6-dimethylbenzene-N,C(2'),N-iridium chloride]; caesium carbonate; In tert-Amyl alcohol; for 12h; Reflux;

DOI:10.1021/acs.joc.6b02758

Reference yield: 80.0%

1-(3-bromophenyl)ethanol (52780-14-0) + benzyl alcohol (100-51-6,185532-71-2) → 1-(3-bromophenyl)-3-phenylpropan-1-one (866821-66-1)

Guidance literature:

With [Ni(dmpymt)₂]₆; potassium hydroxide; In toluene; at 100 ℃; for 24h; chemoselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1039/C9OB00418A

upstream raw materials:

1-(3-bromophenyl)-3-phenylpropan-1-ol

phenethylmagnesium bromide

m-bromobenzoic aldehyde

1-(3-bromophenyl)ethanol

Downstream raw materials:

5-benzyl-4-(3-benzyl-phenyl)-thiazol-2-ylamine

5-benzyl-4-(3-bromo-phenyl)-thiazol-2-ylamine

Refernces

• 1、 Wang, Danfeng,McBurney, Roy T.,Pernik, Indrek,Messerle, Barbara A.. "Controlling the selectivity and efficiency of the hydrogen borrowing reaction by switching between rhodium and iridium catalysts". supporting information. p. 13989 - 13999. Retrieved 2019/10/01.
• 2、 Zhang, Meng-Juan,Li, Hong-Xi,Young, David J.,Li, Hai-Yan,Lang, Jian-Ping. "Reaction condition controlled nickel(ii)-catalyzed C-C cross-coupling of alcohols". supporting information. p. 3567 - 3574. Retrieved 2019/04/14.