7-FLUOROIMIDAZO[2,1-B]BENZOTHIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER

Base Information

Chemical Name:7-FLUOROIMIDAZO[2,1-B]BENZOTHIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER
CAS No.:181486-57-7
Molecular Formula:C12H9FN2O2S
Molecular Weight:264.28
Hs Code.:
Mol file:181486-57-7.mol

Synonyms:7-FLUOROIMIDAZO[2,1-B]BENZOTHIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER

Suppliers and Price of 7-FLUOROIMIDAZO[2,1-B]BENZOTHIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
ETHYL 7-FLUOROIMIDAZO[2,1-B][1,3]BENZOTHIAZOLE-2-CARBOXYLATE 95.00%
10MG
$ 675.51

American Custom Chemicals Corporation
ETHYL 7-FLUOROIMIDAZO[2,1-B][1,3]BENZOTHIAZOLE-2-CARBOXYLATE 95.00%
1MG
$ 628.20

Total 1 raw suppliers

Chemical Property of 7-FLUOROIMIDAZO[2,1-B]BENZOTHIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

PSA：71.84000
LogP:2.86480

Purity/Quality:: ETHYL 7-FLUOROIMIDAZO[2,1-B][1,3]BENZOTHIAZOLE-2-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 7-FLUOROIMIDAZO[2,1-B]BENZOTHIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER

There total 2 articles about 7-FLUOROIMIDAZO[2,1-B]BENZOTHIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 181486-57-7
ethyl 10-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0²^,⁶]dodeca-1⁽⁸⁾,3,5,9,11-pentaene-4-carboxylate

Guidance literature:: In acetonitrile; at 85 ℃; for 12h;

Reference yield: 19.0%

: 348-40-3
2-amino-6-fluoro-1,3-benzothiazole

: 70-23-5
ethyl Bromopyruvate

: 181486-57-7
ethyl 10-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0²^,⁶]dodeca-1⁽⁸⁾,3,5,9,11-pentaene-4-carboxylate

Guidance literature:: In 1,2-dimethoxyethane; for 6h; Heating;
DOI:10.1021/jm049680x

Reference yield:

: 181486-57-7
ethyl 10-fluoro-7-thia-2,5-diazatricyclo[6.4.0.0²^,⁶]dodeca-1⁽⁸⁾,3,5,9,11-pentaene-4-carboxylate

: 623931-28-2
4-nitrobenzyl 6-[(acetyloxy)(7-fluoroimidazo[2,1-b][1,3]benzothiazol-2-yl)methyl]-6-bromo-7-oxo-4-thia-1-azabicylco[3.2.0]hept-2-ene-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: LiBH₄ / tetrahydrofuran / 2 h / Heating

2.1: MnO₂ / CHCl₃ / 24 h / Heating

3.1: MgBr₂*Et₂O / tetrahydrofuran; acetonitrile / 0.5 h / 20 °C

3.2: Et₃N / tetrahydrofuran; acetonitrile / 16 h / -20 °C

3.3: 22 percent / tetrahydrofuran; acetonitrile / -20 - 0 °C

With manganese(IV) oxide; lithium borohydride; magnesium bromide; In tetrahydrofuran; chloroform; acetonitrile;
DOI:10.1021/jm049680x