3-(TRIFLUOROMETHOXY)BENZAMIDOXIME

Base Information

• Chemical Name: 3-(TRIFLUOROMETHOXY)BENZAMIDOXIME
• CAS No.: 886500-80-7
• Molecular Formula: C8H7F3N2O2
• Molecular Weight: 220.15
• Hs Code.: 2910900090
• Mol file: 886500-80-7.mol

Synonyms:3-(TRIFLUOROMETHOXY)BENZAMIDOXIME

Chemical Property of 3-(TRIFLUOROMETHOXY)BENZAMIDOXIME

Chemical Property:

• PSA: 67.84000
• LogP: 2.38000

Purity/Quality:

98%min ^*data from raw suppliers

3-(Trifluoromethoxy)benzamidoxime ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-(Trifluoromethoxy)benzamidoxime is a useful compound in preparation for “one-pot” synthesis of amidoxime.

Technology Process of 3-(TRIFLUOROMETHOXY)BENZAMIDOXIME

There total 3 articles about 3-(TRIFLUOROMETHOXY)BENZAMIDOXIME which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

1-cyano-3-trifluoromethoxybenzene (52771-22-9) → N'-hydroxy-3-(trifluoromethoxy)benzenecarboximidamide (886500-80-7)

Guidance literature:

With hydroxylamine hydrochloride; sodium carbonate; In methanol; water; at 120 ℃; for 12h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c4ob02456g

Reference yield: 46.0%

→ N'-hydroxy-3-(trifluoromethoxy)benzenecarboximidamide (886500-80-7)

Guidance literature:

With hydroxylamine hydrochloride; triethylamine; In tetrahydrofuran; at 65 ℃; for 12h;

Reference yield:

1-bromo-3-(trifluoromethoxy)benzene (2252-44-0) → N'-hydroxy-3-(trifluoromethoxy)benzenecarboximidamide (886500-80-7)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene; sodium carbonate; 1-methyl-pyrrolidin-2-one / 12 h / 120 °C / Schlenk technique; Inert atmosphere

2: sodium carbonate; hydroxylamine hydrochloride / methanol; water / 12 h / 120 °C / Schlenk technique; Inert atmosphere

With 1-methyl-pyrrolidin-2-one; 1,1'-bis-(diphenylphosphino)ferrocene; hydroxylamine hydrochloride; palladium diacetate; sodium carbonate; In methanol; water;

DOI:10.1039/c4ob02456g

upstream raw materials:

1-cyano-3-trifluoromethoxybenzene

1-bromo-3-(trifluoromethoxy)benzene

Downstream raw materials:

(4-methylpiperazin-1-yl) {3-[(5-methyl-3-{3-[3-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenyl}methanone hydrochloride

Refernces

• 1、 -. "SUBSTITUENT-INCLUDING UREA COMPOUND". Paragraph 0444; 0448-0450; 0552-0554. . Retrieved 2021/12/03.