4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylicacid, 5,6-dihydro-5-methyl-6-oxo-8-(phenylmethoxy)-, 1,1-dimethylethyl ester

Base Information

Chemical Name:4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylicacid, 5,6-dihydro-5-methyl-6-oxo-8-(phenylmethoxy)-, 1,1-dimethylethyl ester
CAS No.:162110-31-8
Molecular Formula:C24H25 N3 O4
Molecular Weight:419.48
Hs Code.:

Synonyms:DM 236

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Chemical Property of 4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylicacid, 5,6-dihydro-5-methyl-6-oxo-8-(phenylmethoxy)-, 1,1-dimethylethyl ester

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MSDS Files:: SDS file from LookChem

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Technology Process of 4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylicacid, 5,6-dihydro-5-methyl-6-oxo-8-(phenylmethoxy)-, 1,1-dimethylethyl ester

There total 9 articles about 4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylicacid, 5,6-dihydro-5-methyl-6-oxo-8-(phenylmethoxy)-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: 2769-72-4
tert-Butyl isocyanoacetate

: 162110-26-1
7-(benzyloxy)-4-methyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

: 162110-31-8
DM 236

Guidance literature:: 7-(benzyloxy)-4-methyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; Inert atmosphere; Cooling;

With diethyl chlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; Inert atmosphere; Cooling;

tert-Butyl isocyanoacetate; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 18h; Inert atmosphere; Cooling;

Reference yield:

: 84377-96-8
7-nitro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5-(1H)-dione

: 162110-31-8
DM 236

Guidance literature:: Multi-step reaction with 5 steps

1.1: H₂ / 10 percent Pd/C / ethanol; tetrahydrofuran

2.1: 0.1M H₂SO₄; NaNO₂ / H₂O / 10 h / 0 °C / Acid hydrolysis

2.2: 1.5M Cu(NO₃)2*2H₂O; Cu₂O / H₂O / 2 h / 50 °C / Acid hydrolysis

3.1: 49 percent / K₂CO₃ / dimethylformamide / 60 °C

4.1: NaH / tetrahydrofuran; dimethylformamide / 0.5 h / 0 °C

5.1: NaH / dimethylformamide / 0.5 h / 0 °C

With sulfuric acid; hydrogen; sodium hydride; potassium carbonate; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; 1.1: Hydrogenolysis / 2.1: Diazotization / 2.2: Hydrolysis / 3.1: Alkylation / 4.1: Acylation / 5.1: Substitution;

Reference yield:

: 3415-35-8
4-methyl-3H-1,4-benzodiazepine-2,5-(1H,4H)-dione

: 162110-31-8
DM 236

Guidance literature:: Multi-step reaction with 6 steps

1.1: KNO₃; H₂SO₄

2.1: H₂ / 10 percent Pd/C / ethanol; tetrahydrofuran

3.1: 0.1M H₂SO₄; NaNO₂ / H₂O / 10 h / 0 °C / Acid hydrolysis

3.2: 1.5M Cu(NO₃)2*2H₂O; Cu₂O / H₂O / 2 h / 50 °C / Acid hydrolysis

4.1: 49 percent / K₂CO₃ / dimethylformamide / 60 °C

5.1: NaH / tetrahydrofuran; dimethylformamide / 0.5 h / 0 °C

6.1: NaH / dimethylformamide / 0.5 h / 0 °C

With sulfuric acid; hydrogen; sodium hydride; potassium carbonate; potassium nitrate; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; 1.1: Nitration / 2.1: Hydrogenolysis / 3.1: Diazotization / 3.2: Hydrolysis / 4.1: Alkylation / 5.1: Acylation / 6.1: Substitution;