Technology Process of 1-(4-fluorophenyl)-1,2-dihydro-4-iodo-2-oxopyridine-3-carbaldehyde
There total 3 articles about 1-(4-fluorophenyl)-1,2-dihydro-4-iodo-2-oxopyridine-3-carbaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
2,6-dimethylpyridine; copper diacetate; n-tetradecanoic acid;
In
toluene;
for 96h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium iodide; chloro-trimethyl-silane / acetonitrile / 2.25 h / 15 - 25 °C
2: copper diacetate; n-tetradecanoic acid; 2,6-dimethylpyridine / toluene / 96 h
With
2,6-dimethylpyridine; chloro-trimethyl-silane; copper diacetate; n-tetradecanoic acid; sodium iodide;
In
toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tert.-butyl lithium / tetrahydrofuran / 0.5 h / -78 °C
1.2: 2.75 h / -78 - -20 °C
1.3: 0.5 h / -78 - 0 °C
2.1: sodium iodide; chloro-trimethyl-silane / acetonitrile / 2.25 h / 20 °C
3.1: copper diacetate; n-tetradecanoic acid; 2,6-dimethylpyridine / toluene / 96 h / 20 °C
With
2,6-dimethylpyridine; chloro-trimethyl-silane; tert.-butyl lithium; copper diacetate; n-tetradecanoic acid; sodium iodide;
In
tetrahydrofuran; toluene; acetonitrile;
