8-Fluoroquinolin-6-ol

Base Information

• Chemical Name: 8-Fluoroquinolin-6-ol
• CAS No.: 209353-22-0
• Molecular Formula: C9H6FNO
• Molecular Weight: 163.15
• DSSTox Substance ID: DTXSID701314972
• Mol file: 209353-22-0.mol

Synonyms:8-fluoroquinolin-6-ol;209353-22-0;6-Quinolinol,8-fluoro-(9CI);MFCD18377723;8-Fluoro-6-hydroxyquinoline;8-Fluoro-6-quinolinol;SCHEMBL14242732;DTXSID701314972;AMY26481;SB68034;SY333251;WS-01371;CS-0196991;K10191;A928622

Chemical Property of 8-Fluoroquinolin-6-ol

Chemical Property:

• Boiling Point: 321.9±22.0 °C(Predicted)
• PKA: 8.18±0.40(Predicted)
• PSA: 33.12000
• Density: 1.366±0.06 g/cm3(Predicted)
• LogP: 2.07950
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 163.043341977
• Heavy Atom Count: 12
• Complexity: 165

Purity/Quality:

97% ^*data from raw suppliers

8-Fluoroquinolin-6-ol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=CC(=CC(=C2N=C1)F)O

Technology Process of 8-Fluoroquinolin-6-ol

There total 4 articles about 8-Fluoroquinolin-6-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

8-fluoro-6-methoxyquinoline (209353-21-9) → 8-fluoroquinolin-6-ol (209353-22-0)

Guidance literature:

With hydrogen bromide; for 8h; Heating;

DOI:10.1002/hlca.19980810522

Reference yield:

2-fluoro-4-methoxy-benzoic acid (394-42-3) → 8-fluoroquinolin-6-ol (209353-22-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 96.8 percent / DIPEA, diphenylphosphoryl azide / toluene / 16 h / Heating

2: 80.6 percent / HCl (gas) / methanol

3: 37.86 percent / arsenic(V) oxide hydrate, boric acid, conc. H₂SO₄ / 16 h / 120 °C

4: 89 percent / 48percent aq. HBr / 8 h / Heating

With hydrogenchloride; arsenic pentoxide hydrate; sulfuric acid; diphenylphosphoranyl azide; hydrogen bromide; boric acid; N-ethyl-N,N-diisopropylamine; In methanol; toluene;

DOI:10.1002/hlca.19980810522

Reference yield:

tert-butyl (2-fluoro-4-methoxyphenyl)carbamate (209353-23-1) → 8-fluoroquinolin-6-ol (209353-22-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 80.6 percent / HCl (gas) / methanol

2: 37.86 percent / arsenic(V) oxide hydrate, boric acid, conc. H₂SO₄ / 16 h / 120 °C

3: 89 percent / 48percent aq. HBr / 8 h / Heating

With hydrogenchloride; arsenic pentoxide hydrate; sulfuric acid; hydrogen bromide; boric acid; In methanol;

DOI:10.1002/hlca.19980810522

upstream raw materials:

8-fluoro-6-methoxyquinoline

2-fluoro-4-(methoxy)aniline

2-fluoro-4-methoxy-benzoic acid

tert-butyl (2-fluoro-4-methoxyphenyl)carbamate