Chemical Property of NSC697923
Chemical Property:
- Boiling Point:443.8±40.0 °C(Predicted)
- PSA：101.48000
- Density:1.416±0.06 g/cm3(Predicted)
- LogP:3.93300
- Storage Temp.:?20°C
- Solubility.:DMSO: soluble20mg/mL, clear
- Purity/Quality:
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99%, *data from raw suppliers
NSC697923 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:Xn
- Statements:
22-41
- Safety Statements:
26-39
- MSDS Files:
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SDS file from LookChem
Useful:
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Description
NSC-69723 (343351-67-7) is a selective inhibitor of the E2 ubiquitin-conjugating enzyme, Ubc13-Uev1A. Does not inhibit UbcH5c activity. Impedes the formation of the Ubc13 and inhibits NF-κB activation in activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL) cells.1?Blocks proliferation and survival of both ABC-DLBCL and germinal center B cell-like (GCB)-DLBCL cell lines, and survival of primary DLBCL cells. NSC-69723 acts via covalent bonding to E2 active site thiol.2,3?Induces neuroblastoma cell death via activation of p53 and JNK.4
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Uses
NSC 697923 is a cell-permeable and selective inhibitor of the ubiquitin-conjugating (E2) enzyme Ubc13-Uev1A and exhibits potent cytotoxicity in a panel of Neuroblastoma (NB) cell lines. NSC 697923 also inhibits the proliferation and survival of diffuse large B-cell lymphoma cells (DLBCL).
