1-cyclohexylpiperazine hydrochloride

Base Information

• Chemical Name: 1-cyclohexylpiperazine hydrochloride
• CAS No.: 245487-40-5
• Molecular Formula: C10H21ClN2
• Molecular Weight: 204.74014
• Hs Code.: 2933599090
• Mol file: 245487-40-5.mol

Synonyms:1-cyclohexylpiperazine hydrochloride;1-Cyclohexyl-piperazine dihydrochloride

Chemical Property of 1-cyclohexylpiperazine hydrochloride

Chemical Property:

• PSA: 15.27000
• LogP: 3.09500

Purity/Quality:

95+% ^*data from raw suppliers

1-CyclohexylpiperazineDihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-cyclohexylpiperazine hydrochloride

There total 3 articles about 1-cyclohexylpiperazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.6%

4-cyclohexyl-piperazine-1-carboxylic acid tert-butyl ester (1224935-95-8) → cyclohexylpiperazine Hydrochloride (245487-40-5)

Guidance literature:

With hydrogenchloride; In ethanol; water; at 20 ℃; for 4h; Reflux; Large scale;

Reference yield:

1-bromocyclohexane (108-85-0) → cyclohexylpiperazine Hydrochloride (245487-40-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 2 h / Reflux; Large scale

2: hydrogenchloride / ethanol; water / 4 h / 20 °C / Reflux; Large scale

With hydrogenchloride; potassium carbonate; In ethanol; water; acetonitrile;

Reference yield:

→ 1-cyclohexyl-piperazine dihydrochloride (245487-40-5)

Guidance literature:

upstream raw materials:

1-bromocyclohexane

4-cyclohexyl-piperazine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

cyclohexylpiperazine

Refernces

• 1、 -. "PIPERAZINYL AND DIAZAPANYL BENZAMIDES AND BENZTHIOAMIDES". Page 72. . Retrieved 2008/06/13.