(E,Z)-1-BROMO-1,2-DIPHENYL-2-(4-HYDROXYPHENYL)ETHENE

Base Information

• Chemical Name: (E,Z)-1-BROMO-1,2-DIPHENYL-2-(4-HYDROXYPHENYL)ETHENE
• CAS No.: 874504-11-7
• Molecular Formula: C20H15BrO
• Molecular Weight: 351.24
• Mol file: 874504-11-7.mol

Synonyms:(E,Z)-1-BROMO-1,2-DIPHENYL-2-(4-HYDROXYPHENYL)ETHENE;4-(2-BroMo-1,2-diphenylethenyl)phenol;α'-BroMo-α-phenyl-4-stilbenol

Chemical Property of (E,Z)-1-BROMO-1,2-DIPHENYL-2-(4-HYDROXYPHENYL)ETHENE

Chemical Property:

• Vapor Pressure: 2.59E-08mmHg at 25°C
• Melting Point: 138-142°C
• Boiling Point: 438.9°C at 760 mmHg
• Flash Point: 219.2°C
• PSA: 20.23000
• Density: 1.382g/cm³
• LogP: 5.70370
• Solubility.: Chloroform, Ethyl Acetate

Purity/Quality:

(E,Z)-1-Bromo-1,2-diphenyl-2-(4-hydroxyphenyl)ethene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A chemical with estrogenic properties.

Technology Process of (E,Z)-1-BROMO-1,2-DIPHENYL-2-(4-HYDROXYPHENYL)ETHENE

There total 1 articles about (E,Z)-1-BROMO-1,2-DIPHENYL-2-(4-HYDROXYPHENYL)ETHENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(+/-)-[1-(4-hydroxyphenyl)]-1,2-diphenylethanol (355803-76-8) → (E,Z)-1-bromo-2-[(4-hydroxy)phenyl]-1,2-diphenylethene (874504-11-7,97151-00-3)

Guidance literature:

With bromine; In tetrachloromethane; at 20 ℃; for 1.08333h;

DOI:10.1021/tx020090g

Reference yield: 70.0%

2-chloroethanamine hydrochloride (870-24-6) + (E,Z)-1-bromo-2-[(4-hydroxy)phenyl]-1,2-diphenylethene (874504-11-7,97151-00-3) → (E,Z)-1-bromo-2-[4-(2-aminoethoxy)phenyl]-1,2-diphenylethene (596808-61-6)

Guidance literature:

With potassium hydroxide; In 1,4-dioxane; toluene; Heating;

DOI:10.1021/tx020090g

Reference yield:

(E,Z)-1-bromo-2-[(4-hydroxy)phenyl]-1,2-diphenylethene (874504-11-7,97151-00-3) → (E,Z)-1-bromo-2-[4-[2-(bis(trideuteriomethyl)amino)ethoxy]phenyl]-1,2-diphenylethene

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / KOH / dioxane; toluene / Heating

2: 86 percent / K₂CO₃ / methanol / 48 h / 20 °C

3: 95 percent / PhSNa / butan-2-one / 1 h / Heating

With potassium hydroxide; sodium thiophenolate; potassium carbonate; In 1,4-dioxane; methanol; toluene; butanone;

DOI:10.1021/tx020090g

upstream raw materials:

(+/-)-[1-(4-hydroxyphenyl)]-1,2-diphenylethanol

Downstream raw materials:

(E,Z)-1-bromo-2-[4-(2-aminoethoxy)phenyl]-1,2-diphenylethene