Technology Process of tert-butyl 3-(pyriMidin-2-yl)azetidine-1-carboxylate
There total 3 articles about tert-butyl 3-(pyriMidin-2-yl)azetidine-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl-3-iodoazetidine-1-carboxylate;
With
chloro-trimethyl-silane; ethylene dibromide; zinc;
In
tetrahydrofuran;
at 20 - 50 ℃;
Molecular sieve;
2-bromopyrimidine;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran;
for 25h;
Molecular sieve;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium iodide / N,N-dimethyl-formamide / 16 h / 110 °C
2: zinc; chloro-trimethyl-silane; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; ethylene dibromide / 25 h / 20 °C / Molecular sieve
With
tetrakis(triphenylphosphine) palladium(0); chloro-trimethyl-silane; potassium iodide; zinc;
In
tetrahydrofuran; ethylene dibromide; N,N-dimethyl-formamide;
DOI:10.1021/jm3009635
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 20 h / 0 - 20 °C
2: potassium iodide / N,N-dimethyl-formamide / 16 h / 110 °C
3: zinc; chloro-trimethyl-silane; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; ethylene dibromide / 25 h / 20 °C / Molecular sieve
With
tetrakis(triphenylphosphine) palladium(0); chloro-trimethyl-silane; triethylamine; potassium iodide; zinc;
In
tetrahydrofuran; dichloromethane; ethylene dibromide; N,N-dimethyl-formamide;
DOI:10.1021/jm3009635
