cis-Cyclopropane-1,2-diaMine dihydrochloride

Base Information

• Chemical Name: cis-Cyclopropane-1,2-diaMine dihydrochloride
• CAS No.: 63466-89-7
• Molecular Formula: C₃H₈N₂*2ClH
• Molecular Weight: 145.032
• Mol file: 63466-89-7.mol

Synonyms:cis-Cyclopropane-1,2-diaMine dihydrochloride

Chemical Property of cis-Cyclopropane-1,2-diaMine dihydrochloride

Chemical Property:

• Melting Point: <220 °C (decomp)

Purity/Quality:

98%,99%, ^*data from raw suppliers

(cis)-Cyclopropane-1,2-diamineDihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-Cyclopropane-1,2-diaMine dihydrochloride

There total 7 articles about cis-Cyclopropane-1,2-diaMine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

N,N'-(r-1,t-2-Cyclopropandiyl)dicarbamidsaeure-dibenzylester → (trans)-cyclopropane-1,2-diamine dihydrochloride (3187-76-6,63466-89-7,78678-38-3,78738-31-5,78738-33-7,88526-29-8)

Guidance literature:

With hydrogenchloride; hydrogen; Pd-BaSO₄; In ethanol; water; at 40 ℃; for 120h; under 1875.1 Torr;

Reference yield:

r-1,c-2-Cyclopropandicarbonsaeurediazid (68979-48-6) → cis-cyclopropane-1,2-diamine dihydrochloride (3187-76-6,63466-89-7,78678-38-3,78738-31-5,78738-33-7,88526-29-8)

Guidance literature:

r-1,c-2-Cyclopropandicarbonsaeurediazid; In toluene; Reflux;

With hydrogenchloride; In water; toluene; at 60 ℃; for 2.5h; Cooling with ice;

DOI:10.2174/1570178612666150907204813

Reference yield:

(+/-)-(trans)-N,N'-bis(tert-butyloxycarbonyl)-1,2-cyclopropanediamine → (trans)-cyclopropane-1,2-diamine dihydrochloride (3187-76-6,63466-89-7,78678-38-3,78738-31-5,78738-33-7,88526-29-8)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 2h;

upstream raw materials:

cis-cyclopropane diisocyanate

cis-1,2-cyclopropanedicarboxylic acid

r-1,c-2-Cyclopropandicarbonsaeurediazid

trans-1,2-cyclopropanedicarboxylic acid

Downstream raw materials:

(+/-)-(trans)-N-tert-butyloxycarbonyl-1,2-cyclopropanediamine

trans-N,N'-Bis(4-methylbenzyliden)-1,2-cyclopropandiamin

trans-N,N'-Bis(3,5-dimethylbenzyliden)-1,2-cyclopropandiamin

trans-N,N'-Bis<3,5-di(1,1-dimethylethyl)benzyliden>-1,2-cyclopropandiamin

Refernces

• 1、 Wang, Fan,Xu, Xiao-Ying,Wang, Fei-Ying,Peng, Lin,Zhang, Yong,Wang, Liang-Liang,Wang, Li-Xin. "An efficient and improved process for the scale-up preparation of cis-cyclopropanediamine dihydrochloride". . p. 741 - 744. Retrieved 2016/03/25.
• 2、 Yang, Donglai,Kefi, Slaheddine,Audinot, Valerie,Millan, Mark-J.,Langlois, Michel. "Benzamides derived from 1,2-diaminocyclopropane as novel ligands for human D2 and D3 dopamine receptors". . p. 321 - 327. Retrieved 2007/10/03.