Cyclobutane-1α,2β-dicarboxylic acid

Base Information

• Chemical Name: Cyclobutane-1α,2β-dicarboxylic acid
• CAS No.: 58616-97-0
• Molecular Formula: C6H8O4
• Molecular Weight: 144.127
• Mol file: 58616-97-0.mol

Synonyms:[1S,2S,(+)]-1,2-Cyclobutanedicarboxylic acid

Chemical Property of Cyclobutane-1α,2β-dicarboxylic acid

Chemical Property:

• PSA: 74.60000
• LogP: 0.18180

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclobutane-1α,2β-dicarboxylic acid

There total 45 articles about Cyclobutane-1α,2β-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,3,4,4-Tetrachloro-cyclobut-1-ene-1,2-dicarboxylic acid (89799-95-1) → cis-cyclobutane-1,2-dicarboxylic acid (1124-13-6,3396-14-3,17224-72-5,58616-94-7,58616-97-0,1461-94-5)

Guidance literature:

With hydrogen; platinum(IV) oxide; In water;

Reference yield:

cyclobutane-1,1,2,2-tetracarboxylic acid → cis-cyclobutane-1,2-dicarboxylic acid (1124-13-6,3396-14-3,17224-72-5,58616-94-7,58616-97-0,1461-94-5)

Guidance literature:

at 180 ℃; Behandeln mit Acetylchlorid und Kochen des erhaltenen Anhydrids mit Wasser;

Reference yield:

dimethyl 1-cyanocyclobutane-1,2-dicarboxylate (14132-45-7) → cis-cyclobutane-1,2-dicarboxylic acid (1124-13-6,3396-14-3,17224-72-5,58616-94-7,58616-97-0,1461-94-5)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. HCl / 12 h / Heating

2: 180 °C / water pump

With hydrogenchloride;

DOI:10.1016/S0957-4166(02)00757-7

upstream raw materials:

cis-1,2-divinylcyclobutane

1,2-bis-methanesulfonyl-cyclobutane-1,2-dicarboxylic acid diamide

all-cis-3,4-Dibrom-cyclobutan-dicarbonsaeure-(1,2)-anhydrid

3,3,4,4-Tetrachloro-cyclobut-1-ene-1,2-dicarboxylic acid

Downstream raw materials:

(1S,2S)-α,α,α',α'-tetraphenylcyclobutane-1,2-dimethanol

diethyl trans-1,2-cyclobutanedicarboxylate

(1,2-trans)-1-(2-(4-bromophenyl)-2-oxoethyl) 2-methyl cyclobutane-1,2-dicarboxylate

((1,2-trans)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclobutyl)((R)-3-methylmorpholino)methanone