2-tert-butyl 8a-methyl 3,4,6,7,8,8a-hexahydro-6-oxoisoquinoline-2,8a(1H)-dicarboxylate

Base Information

Chemical Name:2-tert-butyl 8a-methyl 3,4,6,7,8,8a-hexahydro-6-oxoisoquinoline-2,8a(1H)-dicarboxylate
CAS No.:697798-87-1
Molecular Formula:C16H23NO5
Molecular Weight:309.36
Hs Code.:
Mol file:697798-87-1.mol

Synonyms:2-tert-butyl 8a-methyl 3,4,6,7,8,8a-hexahydro-6-oxoisoquinoline-2,8a(1H)-dicarboxylate;2-(tert-butyl)8a-methyl6-oxo-4,6,7,8-tetrahydroisoquinoline-2,8a(1H,3H)-dicarboxylate

Suppliers and Price of 2-tert-butyl 8a-methyl 3,4,6,7,8,8a-hexahydro-6-oxoisoquinoline-2,8a(1H)-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
2-tert-butyl8a-methyl6-oxo-1,2,3,4,6,7,8,8a-octahydroisoquinoline-2,8a-dicarboxylate 95%+
1g
$ 291.00

Total 7 raw suppliers

Chemical Property of 2-tert-butyl 8a-methyl 3,4,6,7,8,8a-hexahydro-6-oxoisoquinoline-2,8a(1H)-dicarboxylate

Chemical Property:

PSA：72.91000
LogP:2.01380

Purity/Quality:

97% ^*data from raw suppliers

2-tert-butyl8a-methyl6-oxo-1,2,3,4,6,7,8,8a-octahydroisoquinoline-2,8a-dicarboxylate 95%+ ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-tert-butyl 8a-methyl 3,4,6,7,8,8a-hexahydro-6-oxoisoquinoline-2,8a(1H)-dicarboxylate

There total 3 articles about 2-tert-butyl 8a-methyl 3,4,6,7,8,8a-hexahydro-6-oxoisoquinoline-2,8a(1H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78-85-3,25120-30-3
2-methylpropenal

: 161491-24-3
methyl 1-tert-butoxycarbonyl-4-oxo-3-piperidinecarboxylate

: 697798-87-1,445312-78-7
6-oxo-4,6,7,8-tetrahydro-3H-isoquinoline-2,8a-dicarboxylic acid 2-tert-butyl ester 8a-methyl ester

Guidance literature:: 2-methylpropenal; methyl 1-tert-butoxycarbonyl-4-oxo-3-piperidinecarboxylate; With iron(III) chloride; In dichloromethane; at 20 ℃; for 18h;

With pyrrolidine; acetic acid; In dichloromethane; at 20 ℃; for 19h;

Reference yield:

: 445312-77-6
rac-1-tert-butyl-3-methyl-4-oxo-3-(3-oxobutyl)piperidine-1,3-dicarboxylate

: 697798-87-1,445312-78-7
6-oxo-4,6,7,8-tetrahydro-3H-isoquinoline-2,8a-dicarboxylic acid 2-tert-butyl ester 8a-methyl ester

Guidance literature:: With pyridine; acetic acid; In dichloromethane; at 23 ℃; for 16h;
DOI:10.1021/ol049831q

Reference yield:

: 4-(1-diethylcarbamoyl-2-methyl-propylamino)-5,6-dihydro-2H-pyridine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester

: 697798-87-1,445312-78-7
6-oxo-4,6,7,8-tetrahydro-3H-isoquinoline-2,8a-dicarboxylic acid 2-tert-butyl ester 8a-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Cu(OAc)2*H₂O / acetone / 16 h / 23 °C

2: pyridine; AcOH / CH₂Cl₂ / 16 h / 23 °C

With pyridine; copper diacetate; acetic acid; In dichloromethane; acetone; 1: Michael addition / 2: Robinson annulation;
DOI:10.1021/ol049831q