2,6-DIMETHYLHIPPURIC ACID

Base Information

• Chemical Name: 2,6-DIMETHYLHIPPURIC ACID
• CAS No.: 187980-98-9
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.229
• Mol file: 187980-98-9.mol

Synonyms:2,6-DIMETHYLHIPPURIC ACID

Chemical Property of 2,6-DIMETHYLHIPPURIC ACID

Chemical Property:

• PSA: 66.40000
• LogP: 1.50870

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-DIMETHYLHIPPURIC ACID

There total 2 articles about 2,6-DIMETHYLHIPPURIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C13H17NO3 → 2,6-dimethyl-hippuric acid (187980-98-9)

Guidance literature:

With water; sodium hydroxide; In 2-methyltetrahydrofuran; at 25 - 28 ℃; for 1h;

DOI:10.1021/op100032s

Reference yield:

2,6-dimethylbenzoyl chloride (21900-37-8) → 2,6-dimethyl-hippuric acid (187980-98-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / 2-methyltetrahydrofuran; water / 0.5 h / Cooling

1.2: 3 h / 10 °C / Cooling

2.1: water; sodium hydroxide / 2-methyltetrahydrofuran / 1 h / 25 - 28 °C

With water; sodium hydrogencarbonate; sodium hydroxide; In 2-methyltetrahydrofuran; water; 1.2: Schotten-Baumann reaction;

DOI:10.1021/op100032s

Reference yield:

2,6-dimethyl-hippuric acid (187980-98-9) + 4-nitrobenzaldehdye (555-16-8) → 4-(4-nitrobenzylidene)-2-(2,6-dimethylphenyl)-5(4H)-oxazolone (1224962-81-5)

Guidance literature:

With sodium acetate; acetic anhydride; In 2-methyltetrahydrofuran; for 24h; Reflux;

DOI:10.1021/op100032s

upstream raw materials:

2,6-dimethylbenzoyl chloride

Downstream raw materials:

4-(4-nitrobenzylidene)-2-(2,6-dimethylphenyl)-5(4H)-oxazolone

4-(4-methoxybenzylidene)-2-(2,6-dimethylphenyl)-5(4H)-oxazolone

Refernces