8-METHYL-3-(TRIFLUOROMETHYL)-5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZINE

Base Information

• Chemical Name: 8-METHYL-3-(TRIFLUOROMETHYL)-5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZINE
• CAS No.: 611240-66-5
• Molecular Formula: C₇H₉F₃N₄
• Molecular Weight: 206.17
• Hs Code.: 2933990090
• Mol file: 611240-66-5.mol

Synonyms:8-METHYL-3-(TRIFLUOROMETHYL)-5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZINE

Chemical Property of 8-METHYL-3-(TRIFLUOROMETHYL)-5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZINE

Chemical Property:

• PSA: 42.74000
• LogP: 1.28990
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

8-Methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-METHYL-3-(TRIFLUOROMETHYL)-5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZINE

There total 2 articles about 8-METHYL-3-(TRIFLUOROMETHYL)-5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

8-methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine (611240-66-5) → (R)-8-methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine (611240-66-5)

Guidance literature:

8-methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine; With O,O'-dibenzoyl-D-tartaric acid; In ethanol; at 20 ℃; for 1h; Resolution of racemate;

With sodium hydroxide; In water; ethyl acetate; at 0 - 10 ℃; for 0.166667h; pH=10 - 11; Reagent/catalyst; Solvent; Temperature;

Reference yield:

8-methyl-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin (611240-65-4) → 8-methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine (611240-66-5)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 16h; under 760.051 Torr;

Reference yield: 39.0%

8-methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine (611240-66-5) → (R)-8-methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine (611240-66-5)

Guidance literature:

8-methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine; With O,O'-dibenzoyl-D-tartaric acid; In ethanol; at 20 ℃; for 1h; Resolution of racemate;

With sodium hydroxide; In water; ethyl acetate; at 0 - 10 ℃; for 0.166667h; pH=10 - 11; Reagent/catalyst; Solvent; Temperature;

upstream raw materials:

8-methyl-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin