Cadazolid

Base Information

• Chemical Name: Cadazolid
• CAS No.: 1025097-10-2
• Molecular Formula: C29H29F2N3O8
• Molecular Weight: 585.561
• Mol file: 1025097-10-2.mol

Synonyms:Cadazolid

Chemical Property of Cadazolid

Chemical Property:

• Boiling Point: 832.6±65.0 °C(Predicted)
• PKA: 6.44±0.41(Predicted)
• PSA: 141.77000
• Density: 1.539±0.06 g/cm3(Predicted)
• LogP: 3.17060

Purity/Quality:

97% ^*data from raw suppliers

Cadazolid(ACT-179811) >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cadazolid

There total 16 articles about Cadazolid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

(R)-3-[3-fluoro-4-(4-hydroxypiperidin-4-ylmethoxy)phenyl]-5-hydroxymethyloxazolidin-2-one (1025097-55-5) + 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid boron diacetate (119489-54-2) → 1-cyclopropyl-6-fluoro-7-[4-({2-fluoro-4-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl] phenoxy}methyl)-4-hydroxypiperidin-1-yl]-4-oxo-1,4-dihydroquinolin-3-carboxylic acid (1025097-10-2)

Guidance literature:

(R)-3-[3-fluoro-4-(4-hydroxypiperidin-4-ylmethoxy)phenyl]-5-hydroxymethyloxazolidin-2-one; 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid boron diacetate; With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 85 ℃; for 5h;

With hydrogenchloride; methanol; water;

Reference yield:

(R)‐3‐(3‐fluoro‐4‐hydroxyphenyl)‐5‐(hydroxymethyl)oxazolidin‐2‐one (1025097-50-0) + methyl-1-cyclopropyl-6-fluoro-7-(1-oxa-6-aza-spiro[2.5]oct-6-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylate → 1-cyclopropyl-6-fluoro-7-[4-({2-fluoro-4-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl] phenoxy}methyl)-4-hydroxypiperidin-1-yl]-4-oxo-1,4-dihydroquinolin-3-carboxylic acid (1025097-10-2)

Guidance literature:

With potassium carbonate; In acetonitrile; for 6h; Reflux;

Reference yield:

(R)‐3‐(3‐fluoro‐4‐hydroxyphenyl)‐5‐(hydroxymethyl)oxazolidin‐2‐one (1025097-50-0) + 1-cyclopropyl-6-fluoro-7-(1-oxa-6-aza-spiro[2.5]oct-6-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid → 1-cyclopropyl-6-fluoro-7-[4-({2-fluoro-4-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl] phenoxy}methyl)-4-hydroxypiperidin-1-yl]-4-oxo-1,4-dihydroquinolin-3-carboxylic acid (1025097-10-2)

Guidance literature:

(R)‐3‐(3‐fluoro‐4‐hydroxyphenyl)‐5‐(hydroxymethyl)oxazolidin‐2‐one; With potassium carbonate; In acetonitrile; for 0.166667h; Reflux;

1-cyclopropyl-6-fluoro-7-(1-oxa-6-aza-spiro[2.5]oct-6-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; In acetonitrile; for 6h; Reflux;

upstream raw materials:

(R)-3-[3-fluoro-4-(4-hydroxypiperidin-4-ylmethoxy)phenyl]-5-hydroxymethyloxazolidin-2-one

7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid boron diacetate

(R)‐3‐(3‐fluoro‐4‐hydroxyphenyl)‐5‐(hydroxymethyl)oxazolidin‐2‐one

1-cyclopropyl-6-fluoro-1,4-dihydro-7-(1,4-dioxa-8-azaspiro<4,5>decan-8-yl)-4-oxoquinoline-3-carboxylic acid

Downstream raw materials:

1-cyclopropyl-6-fluoro-7-{4-[2-fluoro-4-((R)-5-hydroxymethyl-2-oxo-oxazolidin-3-yl)-phenoxymethyl]-4-hydroxy-piperidin-1-yl}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid benzyl ester

7-(4-{4-[(R)-5-(bis-benzyloxy-phosphoryloxymethyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenoxymethyl}-4-hydroxy-piperidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

6-fluoro-7-{4-[2-fluoro-4-((R)-5-hydroxymethyl-2-oxo-oxazolidin-3-yl)-phenoxymethyl]-4-hydroxy-piperidin-1-yl}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

1-cyclopropyl-6-fluoro-7-{4-[2-fluoro-4-((R)-5-hydroxymethyl-2-oxo-oxazolidin-3-yl)-phenoxymethyl]-4-phosphonooxy-piperidin-1-yl}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid