2-Methyl-5,6-dihydro-4H-cyclopenta[d]thiazole-4-carboxylic acid

Base Information

• Chemical Name: 2-Methyl-5,6-dihydro-4H-cyclopenta[d]thiazole-4-carboxylic acid
• CAS No.: 1190391-79-7
• Molecular Formula: C₈H₉NO₂S
• Molecular Weight: 183.231
• Hs Code.: 2934999090
• Mol file: 1190391-79-7.mol

Synonyms:2-Methyl-5,6-dihydro-4H-cyclopenta[d]thiazole-4-carboxylic acid;2-Methyl-5,6-dihydro-4H-cyclopenta-[d][1,3]thiazole-4-carboxylic acid;2-Methyl-4h,5h,6h-cyclopenta[d][1,3]thiazole-4-carboxylicacid

Chemical Property of 2-Methyl-5,6-dihydro-4H-cyclopenta[d]thiazole-4-carboxylic acid

Chemical Property:

• PSA: 78.43000
• LogP: 1.56590
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Methyl-5,6-dihydro-4H-cyclopenta[d]thiazole-4-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of 2-Methyl-5,6-dihydro-4H-cyclopenta[d]thiazole-4-carboxylic acid

There total 3 articles about 2-Methyl-5,6-dihydro-4H-cyclopenta[d]thiazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

ethyl 2-methyl-5,6-dihydro-4H-cyclopenta[d]thiazole-4-carboxylate (1190391-80-0) → 2-methyl-5,6-dihydro-4H-cyclopenta[d]thiazole-4-carboxylic acid (1190391-79-7)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; methanol; at 25 ℃; for 5h; Inert atmosphere;

DOI:10.1021/jm4017224

Reference yield:

2-ethoxycarbonyl-1-cyclopentanone (611-10-9) → 2-methyl-5,6-dihydro-4H-cyclopenta[d]thiazole-4-carboxylic acid (1190391-79-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: bromine / chloroform / 0 - 20 °C

1.3: 20 °C / Reflux

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 3 h / 20 °C

2.2: pH 3

With water; bromine; lithium hydroxide; In tetrahydrofuran; methanol; chloroform;

Reference yield:

ethyl 3-bromo-2-oxocyclopentanecarboxylate (42593-13-5) → 2-methyl-5,6-dihydro-4H-cyclopenta[d]thiazole-4-carboxylic acid (1190391-79-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 25 °C / Inert atmosphere; Reflux

2: lithium hydroxide; water / tetrahydrofuran; methanol / 5 h / 25 °C / Inert atmosphere

With water; lithium hydroxide; In tetrahydrofuran; methanol; ethanol;

DOI:10.1021/jm4017224

upstream raw materials:

ethyl 2-methyl-5,6-dihydro-4H-cyclopenta[d]thiazole-4-carboxylate

2-ethoxycarbonyl-1-cyclopentanone

ethyl 3-bromo-2-oxocyclopentanecarboxylate

Downstream raw materials:

(R)-N-(4-(((2S,5R)-5-((R)-hydroxy(phenyl)methyl)pyrrolidin-2-yl)methyl)phenyl)-2-methyl-5,6-dihydro-4H-cyclopenta[d]thiazole-4-carboxamide

C₃₁H₃₇N₃O₄S

C₃₁H₃₇N₃O₄S

C₃₀H₃₆N₄O₄S

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