Technology Process of 2-(tert-Butoxycarbonyl)-5-thia-2-azaspiro[3.4]octane-8-carboxylic acid 5,5-dioxide
There total 5 articles about 2-(tert-Butoxycarbonyl)-5-thia-2-azaspiro[3.4]octane-8-carboxylic acid 5,5-dioxide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium hydroxide;
In
tetrahydrofuran; water;
at 0 ℃;
for 1h;
Inert atmosphere;
DOI:10.1021/ol2025313
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
1.2: 1 h / -78 °C / Inert atmosphere
2.1: methanesulfonyl chloride; triethylamine / dichloromethane / 3.5 h / 0 - 20 °C / Inert atmosphere
3.1: triethylamine / Inert atmosphere; Reflux
4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C / Inert atmosphere
5.1: lithium hydroxide / tetrahydrofuran; water / 1 h / 0 °C / Inert atmosphere
With
methanesulfonyl chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ol2025313
- Guidance literature:
-
Multi-step reaction with 4 steps
1: methanesulfonyl chloride; triethylamine / dichloromethane / 3.5 h / 0 - 20 °C / Inert atmosphere
2: triethylamine / Inert atmosphere; Reflux
3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C / Inert atmosphere
4: lithium hydroxide / tetrahydrofuran; water / 1 h / 0 °C / Inert atmosphere
With
methanesulfonyl chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hydroxide;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ol2025313
