5,6,12b,13-Tetrahydro-9,10,14-trimethoxy-8H-1,3-dioxolo[4,5-h]isoindolo[1,2-b][3]benzazepin-8-one

Base Information

• Chemical Name: 5,6,12b,13-Tetrahydro-9,10,14-trimethoxy-8H-1,3-dioxolo[4,5-h]isoindolo[1,2-b][3]benzazepin-8-one
• CAS No.: 50347-54-1
• Molecular Formula: C₂₁H₂₁NO₆
• Molecular Weight: 383.401
• Mol file: 50347-54-1.mol

Synonyms:5,6,12b,13-Tetrahydro-9,10,14-trimethoxy-8H-1,3-dioxolo[4,5-h]isoindolo[1,2-b][3]benzazepin-8-one

Chemical Property of 5,6,12b,13-Tetrahydro-9,10,14-trimethoxy-8H-1,3-dioxolo[4,5-h]isoindolo[1,2-b][3]benzazepin-8-one

Chemical Property:

• Melting Point: 207 - 208 °C
• PSA: 66.46000
• LogP: 2.67470

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,6,12b,13-Tetrahydro-9,10,14-trimethoxy-8H-1,3-dioxolo[4,5-h]isoindolo[1,2-b][3]benzazepin-8-one

There total 4 articles about 5,6,12b,13-Tetrahydro-9,10,14-trimethoxy-8H-1,3-dioxolo[4,5-h]isoindolo[1,2-b][3]benzazepin-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4,13-trimethoxy-5-oxo-7,8-dihydro-5H,11H-<1,3>dioxolo<4'',5'':4',5'>benzo<1',2':4,5>azepino<2,1-a>isoindole (50347-53-0) → 9,10,14-trimethoxy-5,6,12b,13-tetrahydro-[1,3]dioxolo[4'',5'':4',5']benzo[1',2':4,5]azepino[2,1-a]isoindol-8-one (50347-54-1)

Guidance literature:

With hydrogen; platinum(IV) oxide; In acetic acid;

Reference yield:

2,3-dimethoxy-6-(4-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]azepin-6-yl)-benzoic acid (38478-58-9) → 9,10,14-trimethoxy-5,6,12b,13-tetrahydro-[1,3]dioxolo[4'',5'':4',5']benzo[1',2':4,5]azepino[2,1-a]isoindol-8-one (50347-54-1)

Guidance literature:

In acetic anhydride;

DOI:10.1139/v72-325

Reference yield:

2,3-dimethoxy-6-(4-methoxy-7-methyl-8,9-dihydro-7H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]azepin-6-yl)-benzoic acid; sodium salt (33529-29-2) → 9,10,14-trimethoxy-5,6,12b,13-tetrahydro-[1,3]dioxolo[4'',5'':4',5']benzo[1',2':4,5]azepino[2,1-a]isoindol-8-one (50347-54-1)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) AcOH, (ii) LiBH₄, THF

2: acetic anhydride

In acetic anhydride;

DOI:10.1139/v72-325

upstream raw materials:

3,4,13-trimethoxy-5-oxo-7,8-dihydro-5H,11H-<1,3>dioxolo<4'',5'':4',5'>benzo<1',2':4,5>azepino<2,1-a>isoindole

2,3-dimethoxy-6-(4-methoxy-7-methyl-6,7,8,9-tetrahydro-5H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]azepin-6-yl)-benzoic acid

2,3-dimethoxy-6-(4-methoxy-7-methyl-8,9-dihydro-7H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]azepin-6-yl)-benzoic acid; sodium salt

Downstream raw materials:

3,4,13-trimethoxy-5-oxo-7,8-dihydro-5H,11H-<1,3>dioxolo<4'',5'':4',5'>benzo<1',2':4,5>azepino<2,1-a>isoindole