(R)-2-AMino-2-(4-trifluoroMethylphenyl)ethanol

Base Information

• Chemical Name: (R)-2-AMino-2-(4-trifluoroMethylphenyl)ethanol
• CAS No.: 306281-86-7
• Molecular Formula: C9H10F3NO
• Molecular Weight: 205.1770096
• Hs Code.: 2922190090
• Mol file: 306281-86-7.mol

Synonyms:(R)-2-AMino-2-(4-trifluoroMethylphenyl)ethanol;(2R)-2-AMINO-2-[4-(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL;(2R)-2-Amino-2-(4-trifluoromethyl-phenyl)-ethanol

Chemical Property of (R)-2-AMino-2-(4-trifluoroMethylphenyl)ethanol

Chemical Property:

• Melting Point: 99 - 100 °C (ethyl acetate)
• Boiling Point: 296.8±35.0 °C(Predicted)
• PKA: 12.33±0.10(Predicted)
• PSA: 46.25000
• Density: 1.301±0.06 g/cm3(Predicted)
• LogP: 2.39780
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99%, ^*data from raw suppliers

(2R)-2-Amino-2-(4-trifluoromethyl-phenyl)-ethanol 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-AMino-2-(4-trifluoroMethylphenyl)ethanol

There total 4 articles about (R)-2-AMino-2-(4-trifluoroMethylphenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(R)-(-)-2-azido-2-[p-(trifluoromethyl)phenyl]ethanol (306282-11-1) → (R)-(-)-2-amino-2-[p-(trifluoromethyl)phenyl]ethanol (306281-86-7,473416-36-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

1-trifluoromethyl-4-vinyl-benzene (402-50-6) → (R)-(-)-2-amino-2-[p-(trifluoromethyl)phenyl]ethanol (306281-86-7,473416-36-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / AD-mix-α; H2O / 2-methyl-propan-2-ol / 3 h / 0 °C

2: 90 percent / NaOH / 4 h / 60 °C

3: 43 percent / aq. NaN₃ / dimethylformamide / 3 h / 110 °C

4: 72 percent / LiAlH₄ / tetrahydrofuran / 2 h / 20 °C

With sodium hydroxide; AD-mix-α; lithium aluminium tetrahydride; sodium azide; water; In tetrahydrofuran; N,N-dimethyl-formamide; tert-butyl alcohol; 1: Sharpless asymmetric dihydroxylation;

Reference yield:

(+)-1-[p-(trifluoromethyl)phenyl]ethane-1,2-diol (306281-87-8) → (R)-(-)-2-amino-2-[p-(trifluoromethyl)phenyl]ethanol (306281-86-7,473416-36-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / NaOH / 4 h / 60 °C

2: 43 percent / aq. NaN₃ / dimethylformamide / 3 h / 110 °C

3: 72 percent / LiAlH₄ / tetrahydrofuran / 2 h / 20 °C

With sodium hydroxide; lithium aluminium tetrahydride; sodium azide; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

(R)-(-)-2-azido-2-[p-(trifluoromethyl)phenyl]ethanol

1-trifluoromethyl-4-vinyl-benzene

(+)-1-[p-(trifluoromethyl)phenyl]ethane-1,2-diol

(S)-(+)-4-[p-(trifluoromethyl)phenyl]-1,3-dioxolan-2-one

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