rac-cis-7-Hydroxy Pramipexole

Base Information

Chemical Name:rac-cis-7-Hydroxy Pramipexole
CAS No.:1001648-71-0
Molecular Formula:C10H17N3OS
Molecular Weight:227.33
Hs Code.:2934200000
Mol file:1001648-71-0.mol

Synonyms:rac-cis-7-Hydroxy Pramipexole;(6S,7S)-;(6S,7S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)-7-benzothiazolol

Suppliers and Price of rac-cis-7-Hydroxy Pramipexole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
rac-cis-7-HydroxyPramipexole
25mg
$ 1455.00

Total 10 raw suppliers

Chemical Property of rac-cis-7-Hydroxy Pramipexole

Chemical Property:

Melting Point:141-143°C
Boiling Point:438.7±45.0 °C(Predicted)
PKA:13.16±0.40(Predicted)
PSA：100.14000
Density:1.27±0.1 g/cm3(Predicted)
LogP:1.39410
Storage Temp.:Hygroscopic, -20?C Freezer, Under Inert Atmosphere
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

NLT 98% ^*data from raw suppliers

rac-cis-7-HydroxyPramipexole ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Pramipexole tetrahydrobenzothiazole derivatives.

Technology Process of rac-cis-7-Hydroxy Pramipexole

There total 8 articles about rac-cis-7-Hydroxy Pramipexole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₀H₁₅N₃OS

: 1001648-71-0,1246818-51-8
(6S,7S)-2-amino-7-hydroxy-6-(propylamino)-4,5,6,7-tetrahydrobenzothiazole

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 ℃; for 4.33333h;

Reference yield:

: 1001648-65-2
(6S,7S)-2,6-diamino-7-hydroxy-4,5,6,7-tetrahydrobenzothiazole

: 123-38-6
propionaldehyde

: 1001648-71-0,1246818-51-8
(6S,7S)-2-amino-7-hydroxy-6-(propylamino)-4,5,6,7-tetrahydrobenzothiazole

Guidance literature:: (6S,7S)-2,6-diamino-7-hydroxy-4,5,6,7-tetrahydrobenzothiazole; propionaldehyde; In methanol; at -20 ℃; for 0.75h;

With sodium tetrahydroborate; In methanol; at -20 - 20 ℃; for 4.5h;
DOI:10.1021/acs.oprd.6b00182

Reference yield:

: 2,6-diamino-7-hydroxy-4,5,6,7-tetrahydrobenzothiazole

: 1001648-71-0,1246818-51-8
(6S,7S)-2-amino-7-hydroxy-6-(propylamino)-4,5,6,7-tetrahydrobenzothiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: water / 3 h / 0 °C

2.1: sodium hydroxide / water

3.1: methanol / 0.75 h / -20 °C

3.2: 4.5 h / -20 - 20 °C

With sodium hydroxide; In methanol; water;
DOI:10.1021/acs.oprd.6b00182