rac-cis-7-Hydroxy Pramipexole

Base Information

• Chemical Name: rac-cis-7-Hydroxy Pramipexole
• CAS No.: 1001648-71-0
• Molecular Formula: C10H17N3OS
• Molecular Weight: 227.33
• Hs Code.: 2934200000
• Mol file: 1001648-71-0.mol

Synonyms:rac-cis-7-Hydroxy Pramipexole;(6S,7S)-;(6S,7S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)-7-benzothiazolol

Chemical Property of rac-cis-7-Hydroxy Pramipexole

Chemical Property:

• Melting Point: 141-143°C
• Boiling Point: 438.7±45.0 °C(Predicted)
• PKA: 13.16±0.40(Predicted)
• PSA: 100.14000
• Density: 1.27±0.1 g/cm3(Predicted)
• LogP: 1.39410
• Storage Temp.: Hygroscopic, -20?C Freezer, Under Inert Atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

NLT 98% ^*data from raw suppliers

rac-cis-7-HydroxyPramipexole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Pramipexole tetrahydrobenzothiazole derivatives.

Technology Process of rac-cis-7-Hydroxy Pramipexole

There total 8 articles about rac-cis-7-Hydroxy Pramipexole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C10H15N3OS → (6S,7S)-2-amino-7-hydroxy-6-(propylamino)-4,5,6,7-tetrahydrobenzothiazole (1001648-71-0,1246818-51-8)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃; for 4.33333h;

Reference yield:

(6S,7S)-2,6-diamino-7-hydroxy-4,5,6,7-tetrahydrobenzothiazole (1001648-65-2) + propionaldehyde (123-38-6) → (6S,7S)-2-amino-7-hydroxy-6-(propylamino)-4,5,6,7-tetrahydrobenzothiazole (1001648-71-0,1246818-51-8)

Guidance literature:

(6S,7S)-2,6-diamino-7-hydroxy-4,5,6,7-tetrahydrobenzothiazole; propionaldehyde; In methanol; at -20 ℃; for 0.75h;

With sodium tetrahydroborate; In methanol; at -20 - 20 ℃; for 4.5h;

DOI:10.1021/acs.oprd.6b00182

Reference yield:

2,6-diamino-7-hydroxy-4,5,6,7-tetrahydrobenzothiazole → (6S,7S)-2-amino-7-hydroxy-6-(propylamino)-4,5,6,7-tetrahydrobenzothiazole (1001648-71-0,1246818-51-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: water / 3 h / 0 °C

2.1: sodium hydroxide / water

3.1: methanol / 0.75 h / -20 °C

3.2: 4.5 h / -20 - 20 °C

With sodium hydroxide; In methanol; water;

DOI:10.1021/acs.oprd.6b00182

upstream raw materials:

(6S,7S)-2,6-diamino-7-hydroxy-4,5,6,7-tetrahydrobenzothiazole

propionaldehyde

(6S,7S)-2,6-diamino-7-hydroxy-4,5,6,7-tetrahydrobenzothiazole D-tartrate salt

1,3-cylohexanedione

Downstream raw materials:

pramipexole

pramipexole dihydrochloride

Refernces

• 1、 -. "Process for producing pramipexole". Page/Page column 10-11. . Retrieved 2008/06/13.