Ethyl 2-(3-chlorophenyl)-2,2-difluoroacetate

Base Information

Chemical Name:Ethyl 2-(3-chlorophenyl)-2,2-difluoroacetate
CAS No.:135334-14-4
Molecular Formula:C10H9ClF2O2
Molecular Weight:234.63
Hs Code.:
DSSTox Substance ID:DTXSID80577543
Wikidata:Q82467577
Mol file:135334-14-4.mol

Synonyms:135334-14-4;Ethyl 2-(3-chlorophenyl)-2,2-difluoroacetate;Ethyl 3-Chloro-alpha,alpha-difluorophenylacetate;Ethyl (3-chlorophenyl)(difluoro)acetate;MFCD11007695;Ethyl (3-Chlorophenyl)-difluoroacetate;SCHEMBL1561435;DTXSID80577543;AC2273;AKOS011073284;CS-12898;SY038855;CS-0211176;(3-Chlorophenyl)difluoroacetic acid ethyl ester;Ethyl3-Chloro-alpha,alpha-difluorophenylacetate;ethyl-2,2-difluoro-2-(3-chlorophenyl)-acetate;(3-chloro-phenyl)-difluoro-acetic acid ethyl ester

Suppliers and Price of Ethyl 2-(3-chlorophenyl)-2,2-difluoroacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Ethyl2-(3-chlorophenyl)-2,2-difluoroacetate
250mg
$ 120.00

Crysdot
Ethyl2-(3-chlorophenyl)-2,2-difluoroacetate 95+%
5g
$ 452.00

Chemenu
Ethyl2-(3-chlorophenyl)-2,2-difluoroacetate 95%
5g
$ 426.00

American Custom Chemicals Corporation
ETHYL-2-(3-CHLOROPHENYL)-2,2-DIFLUOROACETATE 95.00%
5MG
$ 497.13

Alichem
Ethyl2-(3-chlorophenyl)-2,2-difluoroacetate
5g
$ 492.48

AK Scientific
Ethyl2-(3-chlorophenyl)-2,2-difluoroacetate
5g
$ 553.00

Total 10 raw suppliers

Chemical Property of Ethyl 2-(3-chlorophenyl)-2,2-difluoroacetate

Chemical Property:

PSA：26.30000
LogP:2.99490
Storage Temp.:Room temperature.
XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:234.0259135
Heavy Atom Count:15
Complexity:234

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-(3-chlorophenyl)-2,2-difluoroacetate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(C1=CC(=CC=C1)Cl)(F)F

Technology Process of Ethyl 2-(3-chlorophenyl)-2,2-difluoroacetate

There total 4 articles about Ethyl 2-(3-chlorophenyl)-2,2-difluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 625-99-0
3-iodochlorobenzene

: 135334-14-4
2-(3-chlorophenyl)-2,2-difluoroacetic acid ethyl ester

Guidance literature:: ethyl 3-bromo-3,3-difluoropropanoate; With copper bronze; In dimethyl sulfoxide; at 20 ℃; for 1h;

3-iodochlorobenzene; In dimethyl sulfoxide; at 20 ℃; for 72h;

Reference yield: 95.0%

: 135334-14-4
2-(3-chlorophenyl)-2,2-difluoroacetic acid ethyl ester

Guidance literature:: With copper; In dimethyl sulfoxide; at 30 - 50 ℃; for 16h; Inert atmosphere;

Reference yield: 76.0%

: 667-27-6
Ethyl bromodifluoroacetate

: 86364-03-6
3-chloro-1-trifluoromethanesulfonyloxybenzene

: 135334-14-4
2-(3-chlorophenyl)-2,2-difluoroacetic acid ethyl ester

Guidance literature:: With bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; tetrabutylammomium bromide; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; zinc; In tetrahydrofuran; at 60 ℃; for 48h; Inert atmosphere;
DOI:10.1021/acs.orglett.7b00938