3(5H)-Indolizinone,6,7,8,8a-tetrahydro-,(8aS)-(9CI)

Base Information

Chemical Name:3(5H)-Indolizinone,6,7,8,8a-tetrahydro-,(8aS)-(9CI)
CAS No.:359866-35-6
Molecular Formula:C₈H₁₁NO
Molecular Weight:137.181
Hs Code.:
Mol file:359866-35-6.mol

Synonyms:3(5H)-Indolizinone,6,7,8,8a-tetrahydro-,(8aS)-(9CI)

Suppliers and Price of 3(5H)-Indolizinone,6,7,8,8a-tetrahydro-,(8aS)-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AccelPharmtech
(8aS)-6,7,8,8a-tetrahydro-3(5H)-Indolizinone 97.00%
25G
$ 7320.00

AccelPharmtech
(8aS)-6,7,8,8a-tetrahydro-3(5H)-Indolizinone 97.00%
5G
$ 3900.00

AccelPharmtech
(8aS)-6,7,8,8a-tetrahydro-3(5H)-Indolizinone 97.00%
1G
$ 2280.00

Total 1 raw suppliers

Chemical Property of 3(5H)-Indolizinone,6,7,8,8a-tetrahydro-,(8aS)-(9CI)

Chemical Property:

PSA：0.00000
LogP:0.00000

Purity/Quality:: (8aS)-6,7,8,8a-tetrahydro-3(5H)-Indolizinone 97.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3(5H)-Indolizinone,6,7,8,8a-tetrahydro-,(8aS)-(9CI)

There total 7 articles about 3(5H)-Indolizinone,6,7,8,8a-tetrahydro-,(8aS)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 113158-92-2
(1R,8aS)-1-hydroxyhexahydroindolizin-3-one

: 359866-35-6,625852-58-6
6,7,8,8a-tetrahydro-5H-indolizin-3-one

Guidance literature:: With Martins sulfurane; In dichloromethane; at 25 ℃; for 2h;
DOI:10.1021/jo010298r

Reference yield: 82.0%

: 393827-08-2
1-(2-vinylpiperidin-1-yl)propenoate

: 359866-35-6,625852-58-6
6,7,8,8a-tetrahydro-5H-indolizin-3-one

Guidance literature:: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; Heating;
DOI:10.1021/jo0108865

Reference yield:

: 359866-23-2
(4S,5S)-5-but-3-enyl-4-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidin-2-one

: 359866-35-6,625852-58-6
6,7,8,8a-tetrahydro-5H-indolizin-3-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: disiamylborane / tetrahydrofuran / 5 h / 20 °C

1.2: 84 percent / aq. NaOH; aq. H₂O₂ / H₂O / 17 h / 20 °C

2.1: 7.67 percent / Et₃N / CH₂Cl₂ / 1.5 h / 20 °C

3.1: 4.20 g / NaH / dimethylformamide; tetrahydrofuran / 2 h / 20 °C

4.1: 98 percent / TFA / CH₂Cl₂ / 3 h / 20 °C

5.1: 82 percent / Martin sulfurane / CH₂Cl₂ / 2 h / 25 °C

With Martins sulfurane; bis-(1,2-dimethylpropyl)borane; sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo010298r