4-(4-Fluorophenyl)-5-hydroxymethyl-6-isopropyl-2-methylthiopyrimidine

Base Information

Chemical Name:4-(4-Fluorophenyl)-5-hydroxymethyl-6-isopropyl-2-methylthiopyrimidine
CAS No.:895129-11-0
Molecular Formula:C15H17FN2OS
Molecular Weight:292.377
Hs Code.:
Mol file:895129-11-0.mol

Synonyms:4-(4-Fluorophenyl)-5-hydroxymethyl-6-isopropyl-2-methylthiopyrimidine;4-(4-Fluorophenyl)-6-(1-Methylethyl)-2-(Methylthio)-5-pyriMidineMethanol

Suppliers and Price of 4-(4-Fluorophenyl)-5-hydroxymethyl-6-isopropyl-2-methylthiopyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-(4-Fluorophenyl)-5-hydroxymethyl-6-isopropyl-2-methylthiopyrimidine
25mg
$ 350.00

TRC
4-(4-Fluorophenyl)-5-hydroxymethyl-6-isopropyl-2-methylthiopyrimidine
100mg
$ 1190.00

Medical Isotopes, Inc.
4-(4-Fluorophenyl)-5-hydroxymethyl-6-isopropyl-2-methylthiopyrimidine
10 mg
$ 860.00

American Custom Chemicals Corporation
4-(4-FLUOROPHENYL)-5-HYDROXYMETHYL-6-ISOPROPYL-2-METHYLTHIOPYRIMIDINE 95.00%
100MG
$ 2194.50

American Custom Chemicals Corporation
4-(4-FLUOROPHENYL)-5-HYDROXYMETHYL-6-ISOPROPYL-2-METHYLTHIOPYRIMIDINE 95.00%
10MG
$ 779.63

Total 2 raw suppliers

Chemical Property of 4-(4-Fluorophenyl)-5-hydroxymethyl-6-isopropyl-2-methylthiopyrimidine

Chemical Property:

PSA：71.31000
LogP:3.62030
Storage Temp.:-20°C Freezer
Solubility.:Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

95% ^*data from raw suppliers

4-(4-Fluorophenyl)-5-hydroxymethyl-6-isopropyl-2-methylthiopyrimidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 4-(4-Fluorophenyl)-5-hydroxymethyl-6-isopropyl-2-methylthiopyrimidine (cas# 895129-11-0) is a compound useful in organic synthesis.

Technology Process of 4-(4-Fluorophenyl)-5-hydroxymethyl-6-isopropyl-2-methylthiopyrimidine

There total 6 articles about 4-(4-Fluorophenyl)-5-hydroxymethyl-6-isopropyl-2-methylthiopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 160009-35-8
methyl 4-(4-fluorophenyl)-2-(methylsulfanyl)-6-(propan-2-yl)-pyrimidine-5-carboxylate

: 895129-11-0
4-(4'-fluorophenyl)-6-isopropyl-2-methylthio-5-hydroxymethyl-pyrimidine

Guidance literature:: methyl 4-(4-fluorophenyl)-2-(methylsulfanyl)-6-(propan-2-yl)-pyrimidine-5-carboxylate; With diisobutylaluminium hydride; In toluene; at 20 ℃; for 2 - 3h; Cooling with ice/salt;

With water; In toluene;

Reference yield:

: 147118-27-2
ethyl 4-(4-fluorophenyl)-2-(methylsulfanyl)-6-(propan-2-yl)-pyrimidine-5-carboxylate

: 895129-11-0
4-(4'-fluorophenyl)-6-isopropyl-2-methylthio-5-hydroxymethyl-pyrimidine

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -74 ℃; for 1h;
DOI:10.1016/S0968-0896(96)00248-9

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 895129-11-0
4-(4'-fluorophenyl)-6-isopropyl-2-methylthio-5-hydroxymethyl-pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 86.7 percent / piperidine, AcOH / benzene / Heating

2: 1.) HMPA, 2.) DDQ / 1.) 100 deg C, 22 h, 2.) benzene, 30 min

3: DIBAL-H / toluene / 1 h / -74 °C

With piperidine; N,N,N,N,N,N-hexamethylphosphoric triamide; diisobutylaluminium hydride; acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In toluene; benzene;
DOI:10.1016/S0968-0896(96)00248-9