Technology Process of 1-tosyl-1H-indol-7-amine
There total 3 articles about 1-tosyl-1H-indol-7-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
5%-palladium/activated carbon; hydrogen;
In
methanol; water; N,N-dimethyl-formamide;
for 24h;
under 760.051 Torr;
Inert atmosphere;
DOI:10.1021/ja4056239
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 1.08 h / 0 - 20 °C / Inert atmosphere
1.2: 11 h / 65 °C / Inert atmosphere
2.1: 5%-palladium/activated carbon; hydrogen / methanol; water; N,N-dimethyl-formamide / 24 h / 760.05 Torr / Inert atmosphere
With
5%-palladium/activated carbon; hydrogen; sodium hydride;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ja4056239
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 1.08 h / 0 - 20 °C / Inert atmosphere
1.2: 11 h / 65 °C / Inert atmosphere
2.1: 5%-palladium/activated carbon; hydrogen / methanol; water; N,N-dimethyl-formamide / 24 h / 760.05 Torr / Inert atmosphere
With
5%-palladium/activated carbon; hydrogen; sodium hydride;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ja4056239
