Benzenepropanoic acid, 4-Methoxy-.alpha.-oxo-

Base Information

• Chemical Name: Benzenepropanoic acid, 4-Methoxy-.alpha.-oxo-
• CAS No.: 28030-16-2
• Molecular Formula: C10H10O4
• Molecular Weight: 194.187
• Hs Code.: 2918990090
• Mol file: 28030-16-2.mol

Synonyms:Benzenepropanoic acid, 4-Methoxy-.alpha.-oxo-;4-Methoxy-a-oxo-benzenepropanoic acid

Chemical Property of Benzenepropanoic acid, 4-Methoxy-.alpha.-oxo-

Chemical Property:

• Melting Point: 190-192 °C(Solv: water (7732-18-5))
• Boiling Point: 342.8±25.0 °C(Predicted)
• PKA: 2.45±0.54(Predicted)
• PSA: 63.60000
• Density: 1.256±0.06 g/cm3(Predicted)
• LogP: 0.89140

Purity/Quality:

98%min ^*data from raw suppliers

3-(4-METHOXYPHENYL)-2-OXOPROPANOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenepropanoic acid, 4-Methoxy-.alpha.-oxo-

There total 26 articles about Benzenepropanoic acid, 4-Methoxy-.alpha.-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-acetamido-3-(4-methoxyphenyl)-2-propenoic acid (68280-85-3) → 3-(4-methoxyphenyl)-2-oxopropanoic acid (28030-16-2)

Guidance literature:

With hydrogenchloride; In water; for 7h; Reflux;

DOI:10.1016/j.ejmech.2014.05.020

Reference yield: 73.0%

(Z)-2-acetamido-3-(4-methoxyphenyl)-2-propenoic acid (73549-09-4) → 3-(4-methoxyphenyl)-2-oxopropanoic acid (28030-16-2)

Guidance literature:

With hydrogenchloride; In ethanol; for 20h;

DOI:10.1080/07328319308018563

Reference yield: 64.0%

5-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-2-trichloromethyl-[1,3]dioxolan-4-one (127220-30-8,127220-37-5) → 3-(4-methoxyphenyl)-2-oxopropanoic acid (28030-16-2)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; for 5h; Ambient temperature;

DOI:10.1055/s-1989-27439

upstream raw materials:

ethyl 3-cyano-3-(p-methoxyphenyl)-pyruvate

4-(4-methoxybenzylidene)-2-phenyl-5(4H)-oxazolone

2-(hydroxyimino)-3-(4-methoxyphenyl)propanoic acid

2-acetamido-3-(4-methoxyphenyl)-2-propenoic acid

Downstream raw materials:

6-methoxy-3-((Ξ)-4-methoxy-benzylidene)-3H-benzofuran-2-one

4,6-dimethoxy-3-(4-methoxy-benzylidene)-3H-benzofuran-2-one

3-(4-methoxy-phenyl)-2-phenylhydrazono-propionic acid

4-Methoxyphenylacetic acid