2,3-Dehydroxy Atorvastatin Sodium Salt

Base Information

Chemical Name:2,3-Dehydroxy Atorvastatin Sodium Salt
CAS No.:1105067-93-3
Molecular Formula:C33H33FN2O4
Molecular Weight:540.634
Hs Code.:
Mol file:1105067-93-3.mol

Synonyms:2,3-Dehydroxy Atorvastatin Sodium Salt;(2E)-2,3-Dehydroxy Atorvastatin

Suppliers and Price of 2,3-Dehydroxy Atorvastatin Sodium Salt

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2E)-2,3-DehydroxyAtorvastatin
2.5mg
$ 540.00

Total 11 raw suppliers

Chemical Property of 2,3-Dehydroxy Atorvastatin Sodium Salt

Chemical Property:

Melting Point:125-130 °C
Boiling Point:705.7±60.0 °C(Predicted)
PKA:4.62±0.10(Predicted)
PSA：91.56000
Density:1.18±0.1 g/cm3(Predicted)
LogP:7.19180
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

(2E)-2,3-DehydroxyAtorvastatin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (2E)-2,3-Dehydroxy Atorvastatin (Atorvastatin 3-Deoxy-hept-2-enoic Acid Sodium Salt (USP)) is an impurity in the synthesis of Atorvastatin (A791750).

Technology Process of 2,3-Dehydroxy Atorvastatin Sodium Salt

There total 1 articles about 2,3-Dehydroxy Atorvastatin Sodium Salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 345891-62-5
(3R,5R)-methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

: (2Z,5S)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-5-hydroxyhept-2-enoic acid

: 1105067-93-3
(2E,5S)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-5-hydroxyhept-2-enoic acid

: 134523-00-5,110862-48-1
atorvastatin

Guidance literature:: (3R,5R)-methyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate; With dmap; acetic anhydride; triethylamine; In toluene; at 60 ℃; for 2h;

With sodium hydroxide; In tetrahydrofuran; water; toluene; at 25 ℃; for 16h; Further stages.;
DOI:10.1135/cccc20080229