Podocarpan-14β-ol

Base Information

• Chemical Name: Podocarpan-14β-ol
• CAS No.: 5720-71-8
• Molecular Weight: 250.42
• Mol file: 5720-71-8.mol

Synonyms:Podocarpan-14β-ol

Chemical Property of Podocarpan-14β-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Podocarpan-14β-ol

There total 10 articles about Podocarpan-14β-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

4b,8,8-trimethyl-4b,5,6,7,8,8a,9,10-octahydrophenanthren-1-ol → (1R,4aS,4bR,10aS)-4b,8,8-trimethyltetradecahydrophenanthren-1-ol (5720-71-8) + (1S,4aS,4bR,10aS)-4b,8,8-trimethyltetradecahydrophenanthren-1-ol (57760-27-7)

Guidance literature:

With hydrogen; In ethanol; at 180 ℃; for 48h; under 28443.9 Torr; Autoclave;

DOI:10.1021/acs.joc.6b02766

Reference yield:

7-Keto-1-methoxy-8.8.13-trimethyl-5.6.7.8.10.13-hexahydro-phenanthren (106036-75-3) → (1R,4aS,4bR,10aS)-4b,8,8-trimethyltetradecahydrophenanthren-1-ol (5720-71-8)

Guidance literature:

Multi-step reaction with 7 steps

1: LiAlH₄

2: H₂, AcOH / Pd-C

3: CrO₃*2Py

4: aq. HI, AcOH

5: N₂H₄, KOH, diethylene glycol / 195 °C

6: H₂ / Raney-Ni / 118944 Torr

With potassium hydroxide; lithium aluminium tetrahydride; hydrogen iodide; hydrogen; dipyridine chromium trioxide; acetic acid; hydrazine; diethylene glycol; palladium on activated charcoal; nickel;

DOI:10.1021/ja00960a035

Reference yield:

8-Methoxy-1,1,4a-trimethyl-1,2,3,4,4a,9-hexahydro-phenanthren-2-ol (5720-80-9) → (1R,4aS,4bR,10aS)-4b,8,8-trimethyltetradecahydrophenanthren-1-ol (5720-71-8)

Guidance literature:

Multi-step reaction with 6 steps

1: H₂, AcOH / Pd-C

2: CrO₃*2Py

3: aq. HI, AcOH

4: N₂H₄, KOH, diethylene glycol / 195 °C

5: H₂ / Raney-Ni / 118944 Torr

With potassium hydroxide; hydrogen iodide; hydrogen; dipyridine chromium trioxide; acetic acid; hydrazine; diethylene glycol; palladium on activated charcoal; nickel;

DOI:10.1021/ja00960a035

upstream raw materials:

7-Keto-1-methoxy-8.8.13-trimethyl-5.6.7.8.10.13-hexahydro-phenanthren

8-Methoxy-1,1,4a-trimethyl-1,2,3,4,4a,9-hexahydro-phenanthren-2-ol

trans-1,2,3,4,9,10,11,12-Octahydro-8-hydroxy-1,1,12-trimethyl-phenanthren

(+/-) - 14-hydroxy-4α,4β,10α-trimethyl-3-oxo-1,2,3,4,5β,6,7,10-octahydrophenanthrene

Downstream raw materials:

8β(H)-podocarpan-14-one

Refernces