1,6-NAPHTHYRIDIN-4(1H)-ONE, 7-CHLORO-

Base Information

• Chemical Name: 1,6-NAPHTHYRIDIN-4(1H)-ONE, 7-CHLORO-
• CAS No.: 952138-12-4
• Molecular Formula: C₈H₅ClN₂O
• Molecular Weight: 180.593
• Hs Code.: 2933990090
• Mol file: 952138-12-4.mol

Synonyms:1,6-NAPHTHYRIDIN-4(1H)-ONE, 7-CHLORO-;7-Chloro-1H-1,6-naphthyridin-4-one;7-Chloro-1,6-naphthyridin-4(1H)-one

Chemical Property of 1,6-NAPHTHYRIDIN-4(1H)-ONE, 7-CHLORO-

Chemical Property:

• PSA: 45.75000
• LogP: 1.57650

Purity/Quality:

97% ^*data from raw suppliers

7-Chloro-1H-1,6-naphthyridin-4-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 1,6-NAPHTHYRIDIN-4(1H)-ONE, 7-CHLORO-

There total 4 articles about 1,6-NAPHTHYRIDIN-4(1H)-ONE, 7-CHLORO- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

5,7-dichloro-1H-1,6-naphthyridin-4-one (863785-66-4) → 7-chloro-1H-1,6-naphthyridin-4-one (952138-12-4)

Guidance literature:

With acetic acid; zinc; In methanol; at 70 ℃;

Reference yield:

5-[[(2,6-dichloropyridin-4-yl)amino]methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione (863785-65-3) → 7-chloro-1H-1,6-naphthyridin-4-one (952138-12-4)

Guidance literature:

Multi-step reaction with 2 steps

1: diphenylether / 1 h / 220 °C

2: zinc; acetic acid / methanol / 70 °C

With acetic acid; zinc; In methanol; diphenylether;

Reference yield:

2,6-dichloro-[4]pyridylamine (2587-02-2) → 7-chloro-1H-1,6-naphthyridin-4-one (952138-12-4)

Guidance literature:

Multi-step reaction with 3 steps

1: isopropyl alcohol / 3 h / 110 °C

2: diphenylether / 1 h / 220 °C

3: zinc; acetic acid / methanol / 70 °C

With acetic acid; zinc; In methanol; diphenylether; isopropyl alcohol;

upstream raw materials:

5,7-dichloro-1H-1,6-naphthyridin-4-one

5-[[(2-chloropyridin-4-yl)amino]methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione

5-[[(2,6-dichloropyridin-4-yl)amino]methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione

2,6-dichloro-[4]pyridylamine

Downstream raw materials:

4,7-dichloro-1,6-naphthyridine

tert-butyl 2-[4-(7-chloro-1,6-naphthyridin-4-yloxy)-2-methoxyphenyl]acetate

2-[4-(7-chloro-1,6-naphthyridin-4-yloxy)-2-methoxyphenyl]acetic acid

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