N-Vinylacetamide

Base Information

• Chemical Name: N-Vinylacetamide
• CAS No.: 5202-78-8
• Molecular Formula: C4H7NO
• Molecular Weight: 85.1057
• Hs Code.: 2924199090
• European Community (EC) Number: 225-989-8
• UNII: 227WR07D3L
• DSSTox Substance ID: DTXSID0063735
• Nikkaji Number: J297.934I
• Wikipedia: N-Vinylacetamide
• Wikidata: Q15124603
• Mol file: 5202-78-8.mol

Synonyms:N-Vinylacetamide;5202-78-8;N-Ethenylacetamide;Acetamide, N-ethenyl-;Vinylacetamide;UNII-227WR07D3L;28408-65-3;227WR07D3L;EINECS 225-989-8;N-Vinyl acetamide(nva);N-VINYLACETAMIDE 97;Acetamidoethylene;n-vinyl-acetamide;N-vinyl acetamide;ACETAMIDE, N-VINYL-;DTXSID0063735;(C4-H7-N-O)x-;MFCD00081205;AKOS006228452;AS-57341;V0105;D92786;Q15124603

Chemical Property of N-Vinylacetamide

Chemical Property:

• Vapor Pressure: 0.222mmHg at 25°C
• Melting Point: 51-54 °C(lit.)
• Refractive Index: 1.414
• Boiling Point: 207.7 °C at 760 mmHg
• PKA: 14.82±0.46(Predicted)
• Flash Point: 103.6 °C
• PSA: 29.10000
• Density: 0.89g/cm³
• LogP: 0.65690
• Water Solubility.: Soluble in water
• XLogP3: 0
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 85.052763847
• Heavy Atom Count: 6
• Complexity: 67.9

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Vinylacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(=O)NC=C

Technology Process of N-Vinylacetamide

There total 14 articles about N-Vinylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.2%

2-acetylaminoethanol (142-26-7) → acetylaminoethylene (5202-78-8,28408-65-3)

Guidance literature:

With succinic acid anhydride; at 40 - 75 ℃; for 15h; Time; Inert atmosphere;

Reference yield: 70.0%

N-(1-methoxyethyl)acetamide (55204-51-8) → acetylaminoethylene (5202-78-8,28408-65-3)

Guidance literature:

at 550 ℃;

DOI:10.1246/cl.1992.519

Reference yield: 32.0%

2-methyl-4-methyl-4H-oxazolin-5-one (69773-71-3) → acetylaminoethylene (5202-78-8,28408-65-3)

Guidance literature:

at 550 ℃; under 0.1 - 0.2 Torr;

upstream raw materials:

N-(2-chloro-ethyl)-acetamide

1,1-bis-acetylamino-ethane

N-(1-cyanoethyl)acetamide

N-(1-methoxyethyl)acetamide

Downstream raw materials:

methyl β-acetamido-2-oxocyclohexanepropanoate

N-acetyl-α-aminopropionaldehyde

N-acetyl-3-aminopropanaldehyde

1'-naphthacetophenone

Refernces

• 1、 Liu, Rui-Hua,Shan, Qi-Chao,Gao, Ya,Loh, Teck-Peng,Hu, Xu-Hong. "Access to multi-functionalized oxazolines via silver-catalyzed heteroannulation of enamides with sulfoxonium ylides". supporting information. p. 1411 - 1414. Retrieved 2020/10/29.
• 2、 -. "N-(1-HYDROXYETHYL)CARBOXAMIDE COMPOUND AND PROCESS FOR PRODUCING SAME". Page/Page column 18. . Retrieved 2011/12/01.