3-Quinolinecarbonitrile, 4-hydroxy-6-methoxy-7-(2-methoxyethoxy)-

Base Information

Chemical Name:3-Quinolinecarbonitrile, 4-hydroxy-6-methoxy-7-(2-methoxyethoxy)-
CAS No.:622369-42-0
Molecular Formula:C₁₄H₁₄N₂O₄
Molecular Weight:274.276
Hs Code.:
DSSTox Substance ID:DTXSID701152289

Synonyms:622369-42-0;1055968-80-3;3-Quinolinecarbonitrile, 4-hydroxy-6-methoxy-7-(2-methoxyethoxy)-;3-Quinolinecarbonitrile, 1,4-dihydro-6-methoxy-7-(2-methoxyethoxy)-4-oxo-;3-Quinolinecarbonitrile,1,4-dihydro-6-methoxy-7-(2-methoxyethoxy)-4-oxo-;SCHEMBL4786042;BRQIOABUVVYKGF-UHFFFAOYSA-N;DTXSID701152289;1,4-DIHYDRO-6-METHOXY-7-(2-METHOXYETHOXY)-4-OXO-3-QUINOLINECARBONITRILE;3-Quinolinecarbonitrile,4-hydroxy-6-methoxy-7-(2-methoxyethoxy)-;4-hydroxy-6-methoxy-7-(2-methoxy-ethoxy)-quinoline-3-carbonitrile;6-methoxy-7-(2-methoxyethoxy)-4-oxo-1,4,-dihydro-3-quinolinecarbonitrile

Suppliers and Price of 3-Quinolinecarbonitrile, 4-hydroxy-6-methoxy-7-(2-methoxyethoxy)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 3-Quinolinecarbonitrile, 4-hydroxy-6-methoxy-7-(2-methoxyethoxy)-

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:436.348°C at 760 mmHg
Flash Point:217.696°C
Density:1.297g/cm³
XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:274.09535693
Heavy Atom Count:20
Complexity:440

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COCCOC1=C(C=C2C(=C1)NC=C(C2=O)C#N)OC

Technology Process of 3-Quinolinecarbonitrile, 4-hydroxy-6-methoxy-7-(2-methoxyethoxy)-

There total 6 articles about 3-Quinolinecarbonitrile, 4-hydroxy-6-methoxy-7-(2-methoxyethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1055968-76-7
2-(dimethylamino-methyleneamino)-5-methoxy-4-(2-methoxy-ethoxy)-benzoic acid methyl ester

: 75-05-8,26809-02-9
acetonitrile

: 622369-42-0,1055968-80-3
4-hydroxy-6-methoxy-7-(2-methoxy-ethoxy)-quinoline-3-carbonitrile

Guidance literature:: acetonitrile; With n-butyllithium; In tetrahydrofuran; hexanes; at -78 ℃; for 1.5h;

2-(dimethylamino-methyleneamino)-5-methoxy-4-(2-methoxy-ethoxy)-benzoic acid methyl ester; In tetrahydrofuran; hexanes; at -78 - -55 ℃; for 1h;

With acetic acid; In tetrahydrofuran; hexanes; at -55 - 20 ℃;

Reference yield:

: 1055968-76-7
2-(dimethylamino-methyleneamino)-5-methoxy-4-(2-methoxy-ethoxy)-benzoic acid methyl ester

: 622369-42-0,1055968-80-3
4-hydroxy-6-methoxy-7-(2-methoxy-ethoxy)-quinoline-3-carbonitrile

Guidance literature:: With n-butyllithium; acetic acid; acetonitrile; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1.5h;

Reference yield:

: 3943-74-6
4-hydroxy-3-methoxybenzoic acid methyl ester

: 622369-42-0,1055968-80-3
4-hydroxy-6-methoxy-7-(2-methoxy-ethoxy)-quinoline-3-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / Aliquat 336 / acetone / 18 h / Heating / reflux

2.1: nitric acid / acetic acid / 20.58 h

3.1: iron; ammonium chloride / methanol; water / 2 h / Heating / reflux

4.1: 2 h / Heating / reflux

5.1: n-butyllithium / tetrahydrofuran; hexanes / 1.5 h / -78 °C

5.2: 1 h / -78 - -55 °C

5.3: -55 - 20 °C

With n-butyllithium; nitric acid; iron; potassium carbonate; ammonium chloride; Aliquat 336; In tetrahydrofuran; methanol; hexanes; water; acetic acid; acetone;