(2S)-2-Methylpyrrolidine tosylate (2S)-2-Methylpyrrolidine 4-methylbenzenesulphonate

Base Information

• Chemical Name: (2S)-2-Methylpyrrolidine tosylate (2S)-2-Methylpyrrolidine 4-methylbenzenesulphonate
• CAS No.: 1212353-38-2
• Molecular Formula: C12H19NO3S
• Molecular Weight: 257.354
• Hs Code.: 2933998090
• Mol file: 1212353-38-2.mol

Synonyms:(2S)-2-Methylpyrrolidine toluene-4-sulphonate;(2S)-2-Methylpyrrolidine tosylate (2S)-2-Methylpyrrolidine 4-methylbenzenesulphonate;(2S)-2-Methylpyrrolidine toluene-4-sulfonate

Chemical Property of (2S)-2-Methylpyrrolidine tosylate (2S)-2-Methylpyrrolidine 4-methylbenzenesulphonate

Chemical Property:

• PSA: 74.78000
• LogP: 3.40960
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(S)-2-Methylpyrrolidine4-Methylbenzenesulfonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2S)-2-Methylpyrrolidine tosylate (2S)-2-Methylpyrrolidine 4-methylbenzenesulphonate

There total 5 articles about (2S)-2-Methylpyrrolidine tosylate (2S)-2-Methylpyrrolidine 4-methylbenzenesulphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methylpyrrolidine-1-carboxylic acid tert-butyl ester (137496-71-0) → (S)-2-methylpyrrolidine 4-methylbenzenesulfonic acid (1212353-38-2,204387-55-3)

Guidance literature:

Multi-step reaction with 2 steps

1: formic acid / 20 h / 20 °C

2: water

With formic acid; In water;

DOI:10.1002/psc.3228

Reference yield:

(R)-1-<(1,1-dimethylethoxy)carbonyl>-2-pyrrolidinemethanolmethanesulfonate (132482-10-1) → (S)-2-methylpyrrolidine 4-methylbenzenesulfonic acid (1212353-38-2,204387-55-3)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium triethylborohydride / tetrahydrofuran / 4 h / 0 - 20 °C

2: formic acid / 20 h / 20 °C

3: water

With formic acid; lithium triethylborohydride; In tetrahydrofuran; water;

DOI:10.1002/psc.3228

Reference yield:

N-(tert-butoxycarbonyl)-D-proline (37784-17-1,59433-50-0) → (S)-2-methylpyrrolidine 4-methylbenzenesulfonic acid (1212353-38-2,204387-55-3)

Guidance literature:

Multi-step reaction with 5 steps

1: borane-THF / tetrahydrofuran / 0 - 20 °C

2: triethylamine / tetrahydrofuran / 0 - 20 °C

3: lithium triethylborohydride / tetrahydrofuran / 4 h / 0 - 20 °C

4: formic acid / 20 h / 20 °C

5: water

With formic acid; borane-THF; lithium triethylborohydride; triethylamine; In tetrahydrofuran; water;

DOI:10.1002/psc.3228

upstream raw materials:

toluene-4-sulfonic acid

(S)-2-methylpyrrolidine

2-methylpyrrolidine-1-carboxylic acid tert-butyl ester

(R)-1-<(1,1-dimethylethoxy)carbonyl>-2-pyrrolidinemethanolmethanesulfonate

Downstream raw materials:

(S)-2-methyl-1-(4-nitro-3-(trifluoromethyl)phenyl)pyrrolidine

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