2-BROMO-5-CHLOROPYRIDINE-4-BORONIC ACID

Base Information

• Chemical Name: 2-BROMO-5-CHLOROPYRIDINE-4-BORONIC ACID
• CAS No.: 1072952-51-2
• Molecular Formula: C₅H₄BBrClNO₂
• Molecular Weight: 236.26
• Hs Code.: 2933399090
• Mol file: 1072952-51-2.mol

Synonyms:2-BROMO-5-CHLOROPYRIDINE-4-BORONIC ACID;2-bromo-5-chloropyridin-4-ylboronic acid;Boronic acid, B-(2-bromo-5-chloro-4-pyridinyl)-;4-Borono-2-bromo-5-chloropyridine;(2-Bromo-5-chloro-4-pyridinyl)boronic acid

Chemical Property of 2-BROMO-5-CHLOROPYRIDINE-4-BORONIC ACID

Chemical Property:

• PSA: 53.35000
• Density: 1.9 g/cm3
• LogP: 0.17730
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromo-5-chloropyridine-4-boronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-5-CHLOROPYRIDINE-4-BORONIC ACID

There total 1 articles about 2-BROMO-5-CHLOROPYRIDINE-4-BORONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Bromo-5-chloro-pyridine (40473-01-6) + Triisopropyl borate (5419-55-6) + water (7732-18-5) + sodium hydroxide (1310-73-2) → (2-bromo-5-chloropyridin-4-yl)boronic acid (1072952-51-2)

Guidance literature:

2-Bromo-5-chloro-pyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 30 ℃; for 1h;

Triisopropyl borate; In tetrahydrofuran; at -78 - 20 ℃; for 16.5h;

water; sodium hydroxide; In tetrahydrofuran; at 20 - 30 ℃; for 0.5h;

Reference yield:

(2-bromo-5-chloropyridin-4-yl)boronic acid (1072952-51-2) → 2-bromo-5-chloropyridin-4-ol (1196145-66-0)

Guidance literature:

With dihydrogen peroxide; In dichloromethane; at 20 - 30 ℃; for 16h;

Reference yield:

(2-bromo-5-chloropyridin-4-yl)boronic acid (1072952-51-2) → 2-bromo-5-chloro-4-(difluoromethoxy)pyridine

Guidance literature:

Multi-step reaction with 2 steps

1: dihydrogen peroxide / dichloromethane / 16 h / 20 - 30 °C

2: potassium carbonate / N,N-dimethyl acetamide / 1 h / 120 °C / Microwave irradiation

With dihydrogen peroxide; potassium carbonate; In dichloromethane; N,N-dimethyl acetamide;

upstream raw materials:

2-Bromo-5-chloro-pyridine

Triisopropyl borate

water

sodium hydroxide

Downstream raw materials:

2-bromo-5-chloropyridin-4-ol

Refernces