2-(2-chloroethyl)-1,3-dinitrobenzene

Base Information

• Chemical Name: 2-(2-chloroethyl)-1,3-dinitrobenzene
• CAS No.: 52536-99-9
• Molecular Formula: C8H7ClN2O4
• Molecular Weight: 230.608
• Mol file: 52536-99-9.mol

Synonyms:2-(2-chloroethyl)-1,3-dinitrobenzene

Chemical Property of 2-(2-chloroethyl)-1,3-dinitrobenzene

Chemical Property:

• PSA: 91.64000
• LogP: 3.33070

Purity/Quality:

99%,98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-chloroethyl)-1,3-dinitrobenzene

There total 2 articles about 2-(2-chloroethyl)-1,3-dinitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-(2,6-dinitrophenyl)ethanol (77759-08-1) → 1-(2-chloroethyl)-2,6-dinitrobenzene (52536-99-9)

Guidance literature:

With thionyl chloride; In pyridine; r.t., 1h then 80 degC, 15min.;

DOI:10.1002/jhet.5570250202

Reference yield:

2,6-dinitrotoluene (606-20-2) → 1-(2-chloroethyl)-2,6-dinitrobenzene (52536-99-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / potassium t-butoxide / dimethylsulfoxide; 2-methyl-propan-2-ol / r.t., 5min. then 70-75 degC, 10min.

2: 74 percent / SOCl₂ / pyridine / r.t., 1h then 80 degC, 15min.

With thionyl chloride; potassium tert-butylate; In pyridine; dimethyl sulfoxide; tert-butyl alcohol;

DOI:10.1002/jhet.5570250202

Reference yield: 73.0%

1-(2-chloroethyl)-2,6-dinitrobenzene (52536-99-9) → 4-nitro-2,3-dihydro-1H-indole (84807-26-1)

Guidance literature:

With hydrogenchloride; iron; In ethanol; for 2h; Heating;

DOI:10.1002/jhet.5570250202

upstream raw materials:

2-(2,6-dinitrophenyl)ethanol

2,6-dinitrotoluene

Downstream raw materials:

4-nitro-2,3-dihydro-1H-indole

4-nitro-1H-indoIe

Refernces