Benzonitrile, 4-[(1R)-2,2-difluoro-1-hydroxy-3-butenyl]- (9CI)

Base Information

• Chemical Name: Benzonitrile, 4-[(1R)-2,2-difluoro-1-hydroxy-3-butenyl]- (9CI)
• CAS No.: 505068-89-3
• Molecular Formula: C₁₁H₉F₂NO
• Molecular Weight: 209.195
• Mol file: 505068-89-3.mol

Synonyms:Benzonitrile, 4-[(1R)-2,2-difluoro-1-hydroxy-3-butenyl]- (9CI)

Chemical Property of Benzonitrile, 4-[(1R)-2,2-difluoro-1-hydroxy-3-butenyl]- (9CI)

Chemical Property:

• PSA: 44.02000
• LogP: 2.41298

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of Benzonitrile, 4-[(1R)-2,2-difluoro-1-hydroxy-3-butenyl]- (9CI)

There total 7 articles about Benzonitrile, 4-[(1R)-2,2-difluoro-1-hydroxy-3-butenyl]- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-bromo-3,3-difluropropene (420-90-6) + 4-cyanobenzaldehyde (105-07-7) → 4-(2,2-difluoro-1-hydroxybut-3-en-1-yl)benzonitrile (505068-89-3)

Guidance literature:

With indium; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/S0957-4166(02)00612-2

Reference yield: 50.0%

vinyl acetate (108-05-4,9003-20-7) + 4-(2,2-difluoro-1-hydroxybut-3-en-1-yl)benzonitrile (505068-89-3) → (R)-2,2-difluoro-1-(p-cyanophenyl)but-3-en-1-ol (505068-89-3) + (S)-2,2-difluoro-1-(p-cyanophenyl)but-3-en-1-ol (505068-89-3) + (+)-(S)-4-acetoxy-3,3-difluoro-4-(p-cyanophenyl)but-1-ene

Guidance literature:

With pseudomonas fluorescens lipase; In hexane; at 30 ℃;

DOI:10.1016/S0957-4166(02)00612-2

Reference yield: 50.0%

vinyl acetate (108-05-4,9003-20-7) + 4-(2,2-difluoro-1-hydroxybut-3-en-1-yl)benzonitrile (505068-89-3) → (R)-2,2-difluoro-1-(p-cyanophenyl)but-3-en-1-ol (505068-89-3) + (S)-2,2-difluoro-1-(p-cyanophenyl)but-3-en-1-ol (505068-89-3) + (+)-(S)-4-acetoxy-3,3-difluoro-4-(p-cyanophenyl)but-1-ene

Guidance literature:

With pseudomonas fluorescens lipase; In hexane; at 30 ℃;

DOI:10.1016/S0957-4166(02)00612-2

upstream raw materials:

vinyl acetate

4-cyanobenzaldehyde

3-bromo-3,3-difluropropene

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